Theoretical Study of the Anti-Human Immuno-Deficiency Virus TIBO Molecule Confined Into Carbon Nanotubes

Belmiloud, Yamina; Ouraghi, M.; Brahimi, Méziane; Benaboura, Ahmed; Charqaoui, D.; Tangour, Bahoueddine

doi:10.1166/jctn.2012.2150

Cited by 13 publications

(6 citation statements)

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“…To increase the therapeutic efficacy, Cisplatin was already transported by several carriers such as liposomes or polymeric micelles nanoparticles [7][8][9][10][11] or CNTs. 12,13 This vectorization enhances the cellular uptake and protects the molecules from degradation during its way to the nuclear region of cancer cell 14,15 . Drug molecules can thus be either chemically attached to the nanoparticles or be encapsulated inside the nanoparticles 16 .…”

Section: Introductionmentioning

confidence: 99%

Encapsulation into Carbon Nanotubes and Release of Anticancer Cisplatin Drug Molecule

et al. 2015

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Molecular dynamics simulations have been investigated to study the interactions between single-wall carbon nanotubes and an anticancer agent Pt complex (Cisplatin). The optimized diameter of the vector system has been determined to encapsulate in the best conditions the drug molecules. The simulation results show also that several drug molecules can be adsorbed inside the nanotubes, leading to an increased confinement time. Moreover, our simulations show that the release of the drug near a cell membrane model is favored, opening the way to a natural drug nanocapsule.

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Section: Introductionmentioning

confidence: 99%

Encapsulation into Carbon Nanotubes and Release of Anticancer Cisplatin Drug Molecule

et al. 2015

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“…It can serve as the drug carrier to improve the sensibility and specificity of disease detection and diagnosis, and serve as the solid carrier to construct electrochemical sensor with proteins. [4][5][6] However, its security issues are attracting worldwide attention. Because of its own physicochemical properties, the nano-materials can enter into the body through respiratory tract inhalation, gastrointestinal tract absorption, penetration of the skin tissue, injection and other ways, especially through the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Influence of Nano-Manganese Dioxide on Rat Spatial Learning and Memory Function and Its Injury for Rat Ventral Midbrain

Zhang¹,

Hou²,

Li³

et al. 2015

Jnl of Comp & Theo Nano

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Objective: To explore the influence of nano-manganese dioxide on the rat spatial learning and memory function and its injury for rat ventral midbrain. Methods: Under cerebral stereotaxis, the physiological saline was injected into the brains of rats in the control group, while nano-manganese dioxide was injected into the brains of rats in the experimental groups. Morris water maze tests were performed one, two, three and four weeks after the injection, respectively. The ventral brain tissues of rats in each group were separated, and RT-PCR and Western blot were used to detect the expression changes of tyrosine hydroxylase, glial fibrillary acidic protein and inducible nitric oxide synthase in the tissues. Results: Intracerebral injection of nano-manganese dioxide made the rats swim slower in Morris water maze test. Two and three weeks after the injection, the time of finding the platform for rats and the latent period became significantly longer. The search platform strategy changed from tendency type and stochastic type to tendency type and edge type. The analysis results of RT-PCR and Western blot showed that the tyrosine hydroxylase expression level in the rat ventral brain tissues decreased and the expression levels of glial fibrillary acidic protein and inducible nitric oxide synthase increased obviously (P < 0 05). Conclusion: Intracerebral injection of nano-manganese dioxide can affect the rat spatial learning and memory function, cause the destruction of dopaminergic neuron in the rat midbrain, the decrease of tyrosine hydroxylase expression level and the increase of the expression levels of glial fibrillary acidic protein and inducible nitric oxide synthase, and have certain injury for ventral midbrain.

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“…This trend is in good agreement with the results from other species confined inside nanotubes. [37][38][39] Starting from the nanotube (5,5), the confinement energy is less than 1 kcal mol 21 , indicating the absence of significant interactions among the H 2 molecule and the nanotube.…”

Section: Confinement Energymentioning

confidence: 99%

A theoretical study of the dihydrogen molecule confined inside carbon nanotubes

Gtari

Tangour

2013

Int J of Quantum Chemistry

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The aim of this work is to better understand the interaction between the confined dihydrogen molecule and armchair (2,2), (3,3) (4,4), (5,5), and (6,6) single‐walled carbon nanotubes (SWNT) using Restricted Hartree–Fock (RHF) and Density Functional Theory (DFT) methods using B3LYP and CAM‐B3LYP functionals. Depending on the calculation method and its orientation inside the nanotube, H2 binds differently. We found that HH bond length increases when H2 is trapped in CNT (2,2) and decreases for CNT (3,3) and (4,4). The characteristics of confined H2 in (5,5) and (6,6) nanotubes are similar to H2 in a free state. © 2013 Wiley Periodicals, Inc.

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Theoretical Study of the Anti-Human Immuno-Deficiency Virus TIBO Molecule Confined Into Carbon Nanotubes

Cited by 13 publications

References 1 publication

Encapsulation into Carbon Nanotubes and Release of Anticancer Cisplatin Drug Molecule

Encapsulation into Carbon Nanotubes and Release of Anticancer Cisplatin Drug Molecule

Influence of Nano-Manganese Dioxide on Rat Spatial Learning and Memory Function and Its Injury for Rat Ventral Midbrain

A theoretical study of the dihydrogen molecule confined inside carbon nanotubes

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