Theoretical study of hypericin

Guedes, Rita C.; Eriksson, Leif A.

doi:10.1016/j.jphotochem.2004.12.025

Cited by 69 publications

(56 citation statements)

References 41 publications

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“…It also exhibits anti-inflammatory and antiangiogenic (Donà et al, 2004) effects. The naturally occurring red pigments hypericin and pseudoyhpericin have been reported to exhibit important biological activities, namely, photodynamic, antiviral, antiretroviral, antibacterial, antipsoriatic, antidepressant and antitumoral activities (Guedes & Eriksson, 2005). Flavonoids are a group of bioactive phenolics present in Hypericum plants.…”

Section: Research Articlementioning

confidence: 99%

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Çırak

Radušienė

Camas

et al. 2013

Pharmaceutical Biology

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Section: Research Articlementioning

confidence: 99%

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Çırak

Radušienė

Camas

et al. 2013

Pharmaceutical Biology

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“…Hypericins, the naturally occurring red pigments have been reported to exhibit significant bioactivities namely, antiviral, antiretroviral, photodynamic, antibacterial, antidepressant and antitumoral activities (Guedes, Eriksson, 2005). Although hyperforin and hypericins have been reported to mainly contribute to the pharmacological effects of Hypericum extracts, flavonoids, which are well known as antioxidants have also made an important contribution to the antidepressant activity (Gastpar, Zeller, 2005;Cirak, 2007;Cirak et al, 2010;Bertoli et al, 2011;Khan et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Secondary metabolites in Hypericum species and their distribution in different plant parts

Odabas

Radušienė

Ivanauskas

et al. 2016

Zemdirbyste-Agriculture

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The genus Hypericum (Hypericaceae) has attracted remarkable scientific interest as its members accumulate significant amounts of various bioactive compounds. In the current study, we investigated accumulation of several bioactive compounds in various parts of Hypericum hircinum L. subsp. majus (Ainton) N. Robson, H. pallens Banks et Sol., H. russeggeri (Fenzl) R. Keller and H. lanuginosum Lam. The plant materials were harvested at flowering, dissected into different tissues and subsequently subjected to high performance liquid chromatography (HPLC) analyses. Accumulation level of the investigated compounds varied greatly depending on species and plant parts. Among different plant tissues, flowers were found to be superior to leaves with respect to accumulation of the chemicals tested except for neochlorogenic, caffeic and 2,4-dihydroxybenzoic acids which were accumulated mainly in leaves. H. hircinum did not produce quercitrin or avicularin, H. lanuginosum did not accumulate hyperforins and caffeic acid, rutin was detected only in H. pallens. For the first time, chemical profiles of these Turkish species of Hypericum were reported and the results are discussed from a phytochemical point of view. The present data could be helpful in selecting the future targets for phytochemical and biological studies on Hypericum genus as well as enriching our current knowledge about Hypericum chemistry.

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“…Hypericum species carry secretory structures in above-ground organs (Soelberg et al, 2007), which are sites of synthesis and accumulation of biologically active substances (Ciccarelli et al, 2001;Onelli et al, 2002), primarily hypericin, pseudohypericin and their derivates protohypericin and protopseudohypericin (Bombardelli and Morazzoni, 1995). Hypericin and pseudohypericin, which are the basic chemicals of Hypericum extracts, are formed in sepals, petals, and stamens of Hypericum species (Zobayed et al, 2006), and these compounds have photodynamic, antiviral, antibacterial, antidepressant and antitumoral activities (Agostinis et al, 2002;Guedes and Eriksson, 2005).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Hypericin Induction in Calli Cultures of Hypericum sinaicum (L.)

Khlifa¹,

Ibrahim²,

Bekhit³

et al. 2016

Int. J. Curr. Res. Biosci. Plant Biol.

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A b s t r a c t A r t i c l e I n f oSufficient and promising protocol for enhancement and production of hypericin in calli cultures of Hypericum sinaicum was established. The highest value of calli cultures was produced from nodal segment and root explants respectively. MS-medium supplemented with 3 mg/l of 2,4-D gave the best results of calli production under dark condition. However, the lowest calli frequency (28 and 20%) and fresh weights (1.4 and 1.0 g/Jar) were estimated with nodal and root explants cultured on MS medium supplemented with 0.25 mg/l 2,4-D + 0.25 mg/l TDZ under light condition. Calli growth dynamics were investigated during five weeks of cultivation. Total hypericin produced by calli cultures derived from nodal segment and root explant were evaluated using HPLC.

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Theoretical study of hypericin

Cited by 69 publications

References 41 publications

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Secondary metabolites in Hypericum species and their distribution in different plant parts

Stimulation of Hypericin Induction in Calli Cultures of Hypericum sinaicum (L.)

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