Theoretical study of diffusional release of a dispersed solute from cylindrical polymeric matrix: A novel configuration for providing zero-order release profile

Jahromi, Arash Khorrami; Shieh, Hamed; Saadatmand, Maryam

doi:10.1016/j.apm.2019.03.044

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…The analyte (10 μL) was injected into the HPLC system and separated at 30 °C, using a constant flow rate of 1.0 mL min –1 at a detection wavelength of 245 nm. 36 The retention time of avermectin B2 was approximately 12.7 min. The EE was calculated according to eq 1 as follows …”

Section: Methodsmentioning

confidence: 97%

“…The HPLC separation of avermectin B2 was carried out on an EcoPak 120 C18 column (150 mm × 4.6 mm, 5 μm, Nano Chromechnology Co., Ltd.), with the isocratic elution of methanol/acetonitrile/water (40:40:20, v/v/v) as the mobile phase. The analyte (10 μL) was injected into the HPLC system and separated at 30 °C, using a constant flow rate of 1.0 mL min –1 at a detection wavelength of 245 nm . The retention time of avermectin B2 was approximately 12.7 min.…”

Section: Methodsmentioning

confidence: 99%

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Preparation and Characterization of Avermectin B2 Microcapsules and Effective Control of Root-Knot Nematodes

Wang

Yan

et al. 2023

ACS Omega

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Polyurethane microcapsules of avermectin B2 were prepared by means of interfacial polymerization with methylene diphenyl diisocyanate as the wall material and triethanolamine as the initiator. The microcapsules were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The surfaces of the microcapsules were found to be smooth and almost spherical, and the encapsulation efficiency was high. The avermectin B2 microcapsules exhibited a good diffusion-controlled sustained-release performance, giving a cumulative release rate of 91.81%. The results indicated that the polyurethane capsule protected against the photolysis of avermectin B2. Finally, the microcapsules exhibited good soil leaching properties and were able to control the population of root-knot nematodes with an efficacy of 80.80%.

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Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Avermectin B2 Microcapsules and Effective Control of Root-Knot Nematodes

Wang

Yan

et al. 2023

ACS Omega

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“…The release profile of riboflavin from the hydrogel was described by the zero-order model (Jahromi et al, 2019), the first-order model (Timotius et al, 2020), the Ritger-Peppas model (Wang et al, 2021), and the Higuchi model (Wang et al, 2021), as expressed in equations [7], [8], [9], and [10], respectively:…”

Section: Gel Microstructurementioning

confidence: 99%

Influence of ultrasound and enzymatic cross-linking on freeze-thaw stability and release properties of whey protein isolate hydrogel

Zhao¹,

Yan²,

Xue

et al. 2022

Journal of Dairy Science

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This study investigated the effect of ultrasound and enzymatic cross-linking on the freeze-thaw (FT) stability and release properties of whey protein isolate hydrogels. We evaluated the FT stability by the changes in the microstructure, riboflavin retention, syneresis, water holding capacity (WHC), and texture of gels subjected to 3 FT cycles. High-intensity ultrasound (HUS) and transglutaminase (TGase)-mediated cross-linking improved the FT stability of whey protein isolate hydrogels loaded with riboflavin (WPISAR), as demonstrated by a more uniform and denser porous structure, significantly higher riboflavin retention, WHC, and textural properties, and lower syneresis after 3 FT cycles than those of untreated hydrogels. Furthermore, HUS-and TGase-mediated cross-linking decreased protein erosion and swelling ratio of WPISAR in simulated gastrointestinal fluids (SGIF) and reduced the riboflavin release rate in SGIF both with and without the addition of digestive enzymes. After 3 FT cycles, faster riboflavin release occurred due to a more porous structure induced by ice crystal formation compared with their unfrozen counterparts as detected by confocal laser scanning microscopy. High-intensity ultrasound-and TGase-mediated cross-linking alleviated the FT-induced faster riboflavin release rate in SGIF. High-intensity ultrasound-and TGase-treated gel samples showed that both diffusion and network erosion were responsible for riboflavin release regardless of FT. These results suggest that HUS-and TGase-mediated cross-linking improved the FT stability of WPISAR with a high riboflavin retention, and might be a good candidate as a controlled-release vehicle for riboflavin delivery to overcome undesired FT processing.

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“…In this case, the drug is homogeneously dispersed in the matrix. Indeed, the release of the drug away from the release surfaces, the water or the medium, takes longer to migrate through the thickness of the polymer [2,35]. This study is applicable in all cases of drug delivery as stents, ear pads, patches, and contact lenses [6,34,[36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Abbasnezhad

Shirinbayan

Tcharkhtchi

et al. 2020

Journal of Drug Delivery Science and Technology

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Drug-eluting implants with a polymeric matrix are currently widely used and the interest of modeling their behavior is increasing. This article aims to present preliminary results of an in vitro under steady flow, study the behavior of drug-loaded polyurethane samples used as drug delivery matrices. Polyisocyanate and polyol synthesis supplied the polyurethane studied in this work. A molding and heat at 50°C for about 30 min make it possible to prepare films from these components. The prepared samples are placed in the impermeable Plexiglas tube and they are in contact with the medium (distilled water). Tests have been performed without flow and three other cases with steady flow, at a temperature of 37°C. The substance active incorporated in these films, as the drug, for carrying out the release tests is the C 20 H 24 C 12 N 2 O 3. This drug supplied in granular form is composed of a mixture in the following proportions, 15 mg of diclofenac epolamine and 50 mg of diclofenac-sodium. Four sample variants were carefully prepared: pure-PU and PU loaded in a mass ratio of 10, 20 or 30%. Weighing, DSC, FT-IR, and DMTA are the methods used to analyze the samples. In addition, SEM micrographs are used to explore qualitatively the microstructure during the release tests. The kinetics in vitro of the drug release and water absorption by the polyurethane films are discussed in detail. The results show that these two quantities depend on the initial drug loading and the flow rate value, as a function of the in vitro incubation time.

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Theoretical study of diffusional release of a dispersed solute from cylindrical polymeric matrix: A novel configuration for providing zero-order release profile

Cited by 8 publications

References 20 publications

Preparation and Characterization of Avermectin B2 Microcapsules and Effective Control of Root-Knot Nematodes

Preparation and Characterization of Avermectin B2 Microcapsules and Effective Control of Root-Knot Nematodes

Influence of ultrasound and enzymatic cross-linking on freeze-thaw stability and release properties of whey protein isolate hydrogel

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

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