“…PCA have been used to find new potential molecules in a series of biological systems (Carotti, 2003, de Paula, 2009de Paula, 2007;Li, 2009;Nascimento, 2011;Nascimento, 2008;Rocha, 2011;Steindl, 2005). A methodology based on PCA for the pharmacophore identification of the acetylcholinesterase inhibitors (AChEI) was recently used (de Paula, 2009;de Paula, 2007;Fang, 2011;Nascimento, 2011;Nascimento, 2008).…”