Abstract:The reaction mechanism of Pd2+-catalyzed regioselective C–H alkylation of indole with MesICH2CF3OTf has been investigated by the density functional theory calculations. The reaction mechanism mainly contains four steps:C-H activation, oxidative addition, reductive elimination and ligands substitution. From our calculations, we find that the C-H activation step was realized by the acetate anion (-OAc) assisted CMD process and the transition state of C-H activation process is a square planar configuration. Moreo… Show more
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