Theoretical prediction of broadband ambient light optogenetic vision restoration with ChRmine and its mutants
Himanshu Bansal,
Gur Pyari,
Sukhdev Roy
Abstract:Vision restoration is one of the most promising applications of optogenetics. However, it is limited due to the poor-sensitivity, slow-kinetics and narrow band absorption spectra of opsins. Here, a detailed theoretical study of retinal ganglion neurons (RGNs) expressed with ChRmine, ReaChR, CoChR, CatCh and their mutants, with near monochromatic LEDs, and broadband sunlight, halogen lamp, RGB LED light, and pure white light sources has been presented. All the opsins exhibit improved light sensitivity and large… Show more
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