Theoretical molecular predictions and antimicrobial activities of newly synthesized molecular hybrids of norfloxacin and ciprofloxacin

Abstract

Antibiotics such as norfloxacin and ciprofloxacin are used to treat numerous bacterial infections. The present research work involves the molecular prediction, synthesis, characterization and in vitro antimicrobial activities of molecular hybrids of norfloxacin and ciprofloxacin. First set of compounds involve the substitutions of various amines at third position of ciprofloxacin and norfloxacin. On the other hand, second set of molecular hybrids include the substitution of different amines at seventh position along with linker (─COCH 2 ─). These synthesized compounds were identified by TLC technique and well characterized by various spectroscopic techniques such as IR, NMR,and ESI-MS. Molecular prediction of these newly synthesized compounds have been carried out using the SwissADME, ADMETLab software. Their cytotoxic-

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

“…Kaur et al [ 34 ] synthesized a series of 3- and 7- substituted-quinoline hybrids derived from fluoroquinolone and studied their antimicrobial properties. The reaction pathway involves the reaction of fluoroquinolone derivatives with the corresponding reagents, when the quinoline hybrids 97 – 104a , b are obtained, Scheme 28 and Scheme 29 .…”

Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureus

“…2-Hydroxy-3- O -tigloylswietenolide does not fit in Ghose´s rules due to the molar refractivity, the total number of atoms and molecular weight are all higher than the typical values for drugability ( Table S1 ). The total polar surface area (TPSA)—a parameter included in both Veber and Varma´s rules—is used as a tool to estimate the transport pathway of the particular type of drug [ 48 ]. The TPSA value for 2-hydroxy-3- O -tigloylswietenolide is 149.57 Å, slightly higher than 140 Å—upper in Veber´s rules—and much higher than Varma´s predictions (TPSA ≤120 Å) ( Table S1 ).…”

Synthesis and studies of new purines/pyrimidine derivatives as multi-targeted agents involving various receptor sites in the immune system

“…The reaction mixture was filtered, and the resulting solid was dissolved in dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and after the removal of solvent, pure sample was obtained (Scheme 1 ) [ 44 , 45 ].

Scheme 1 Synthesis of new compounds

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“…The reaction was filtered and resulting solid was dissolved in acetonitrile. The compound was extracted using petroleum ether, further pure compound was collected after recrystallization using acetonitrile [ 45 – 49 ].…”