Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics

Abstract

Aim. Formation of the basic structures for virtual libraries is an important step during the docking studies, which are currently used in the search of new substances. For the purpose of the logical framework approach use in the planning stages of research we have analyzed the current assortment and mechanisms of action for drugs with spasmolytic action according to their chemical structure.Results. It has been established that the most probable mechanism of action for amidated derivatives of 2-hydroxy-4-oxo-4H-pyrido [1,2α]pyrimidine-3-carboxylic acid, which are substituted in the pyridine ring, in the presence of similar structural fragments is the base inhibition of PDE.