“…Importantly, the photophysical and biological properties of iridium( iii ) complexes can be readily tuned through ligand choice and these compounds have been employed as powerful tools for biological imaging, therapy and sensing applications. 10,20,22,26–28 For example, pH-sensitive phosphorescent iridium( iii ) complexes have been evaluated for monitoring pH in physiological and pathological processes. 28–33 The capacity to monitor pH is crucial as abnormal pH has been associated with several disease states including cancer where intensive respiration can lead to low (acidic) pH values, 34,35 and chemical sensors that allow pH to be monitored represent useful biochemical tools.…”