Abstract:The quantitative analysis of receptor-mediated effect is based on experimental concentration-responsedata in which the independent variable, the concentration of a receptor ligand, is linked with a dependent variable, the biological response. The steps between the drug–receptor interactionand the subsequent biological effect are to some extent unknown.The shape of the fitting curve of the experimental data may give some insights into the nature of the concentration–receptor–response(C-R-R) mechanism. It can be… Show more
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