Abstract:The speed of travel of punches during compaction by a Manesty F3 single punch and D3B Rotary punch tablet machine has been derived from machine dimensions, normal operating speeds and by consideration of the consolidation of a theoretical compact. The analysis may also be used for machines with other dimensions, operating at different speeds with other materials, but would require modification if the punch head design on the rotary machine differed significantly. Punch speeds at the beginning of the compressio… Show more
“…These results contradict the early findings of Sawayanagi et al [ 45 ], probably due to the method of compression they were using. In the later work, a hydraulic tablet press with a compression duration time of 30 s was used for tablet compression whereas in the former work [ 46 ] a single station tableting machine was used with a dwell time generally estimated to be less than 0.1 s [ 47 ].…”
Section: Chitin and Chitosan For Direct Compression Processingmentioning
Despite the numerous uses of chitin and chitosan as new functional materials of high potential in various fields, they are still behind several directly compressible excipients already dominating pharmaceutical applications. There are, however, new attempts to exploit chitin and chitosan in co-processing techniques that provide a product with potential to act as a direct compression (DC) excipient. This review outlines the compression properties of chitin and chitosan in the context of DC pharmaceutical applications.
“…These results contradict the early findings of Sawayanagi et al [ 45 ], probably due to the method of compression they were using. In the later work, a hydraulic tablet press with a compression duration time of 30 s was used for tablet compression whereas in the former work [ 46 ] a single station tableting machine was used with a dwell time generally estimated to be less than 0.1 s [ 47 ].…”
Section: Chitin and Chitosan For Direct Compression Processingmentioning
Despite the numerous uses of chitin and chitosan as new functional materials of high potential in various fields, they are still behind several directly compressible excipients already dominating pharmaceutical applications. There are, however, new attempts to exploit chitin and chitosan in co-processing techniques that provide a product with potential to act as a direct compression (DC) excipient. This review outlines the compression properties of chitin and chitosan in the context of DC pharmaceutical applications.
“…To d o this it is necessary to provide the system with co-ordinates of punch position with respect to time". Punch displacement profiles can be calculated from machine and punch geometry for each press using the equations of Rippie & Danielson (1981) or Charlton & Newton (1984). However, these calculations d o not take machine deformations and deflec- tions into account, and as shown in Fig.…”
An indirect method of calculating punch displacement on a rotary tablet press from measurements of the change in punch force with the turret position was in good agreement with direct measurements of punch displacement made using a linear variable displacement transducer (LVDT)-slip ring system. The direct measurements were made during the compaction of three direct compression agents using Manesty punches. However, the agreement between calculated and experimentally determined punch displacements was unsatisfactory when IPT punches were used. The IPT punches have a much flatter punch head profile than the Manesty punches. Due to this difference, the analytic equation does not accurately describe the dynamics of the press under normal operating conditions. Terms in the analytic equation, determined originally under static conditions, were re-evaluated under dynamic conditions for both sets of tooling using the LVDT-slip ring system. Excellent agreement for both IPT and Manesty punches was found between punch displacement calculated using the revised analytic equation and direct experimental measurements. Punch displacements determined from punch head profile and machine geometry only, without taking machine deformations into account, were shown to differ widely from the calculated and experimental values.
“…During the compression cycle, the slope at the point of contact for both the punch head and the pressure roll must be the same. Using this relationship we derived an equation similar to that of Rippie & Danielson (I98 1) and of Charlton & Newton (1984). Calculated displacements, however, as pointed out by Armstrong & Palfrey (1987), only describe punch movement into and out of an empty die, i.e.…”
To calculate the work of compaction during tableting it is necessary to have accurate values of force and punch displacement. The direct measurement of punch displacement on a rotary press is both costly and complicated but calculated displacements will be in considerable error unless deflections in the press during compression, are taken into account. By analysing the physical restraints imposed on the punches during tablet compression, an expression for punch displacement was derived. From preliminary measurements made on the table press of machine deflections and punch displacement under static conditions, the terms of this expression were evaluated for dynamic conditions. This analytic solution was then used to determine the true punch displacement and work of compaction from direct measurements of vertical force and turret position.
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