Theoretical characterization of two-photon fluorescent probes for nitric oxide detection: sensing mechanism, photophysical properties and protonation effects

Abstract

Nitric oxide (NO) is an important signal molecule in biological systems and correlated with many physiological processes and pathological diseases. To date, numerous fluorescent probes based on o-diamino aromatics have...

Newly Designed Quasi-intrinsic Photosensitizers for Fluorescence Image-Guided Two-Photon Photodynamic Therapy with Type I/II Photoreactions

“…Although there are numerous effective agents in cancer treatment, the PDT is limited by its poor penetrability upon one-photon excitation and minimal light damage to biological tissues. To overcome the above deficiencies, the two-photon photodynamic therapy (TP-PDT) has attracted great attention with considering its longer excitation wavelength and deeper tissue penetration. ,− Recently, Zn­(II) polypyridyl complexes and thionated NpImidazole derivatives have been proposed as effective PSs for TP-PDT . Moreover, Zhou et al demonstrated that the lipid-droplet targeting PS (6DBF2) possesses outstanding therapeutic efficacy in TP-PDT through in vitro cancer cell ablation and in vivo tumor ablation inside mice models.…”