Theoretical and experimental study of ON-Resonance Saturation, an MRI sequence for positive contrast with superparamagnetic nanoparticles

Delangre, Sébastien; Vuong, Quoc Lam; Henrard, Daniel; Magat, Julie; Po, Chrystelle; Gallez, Bernard; Gossuin, Yves

doi:10.1016/j.jmr.2015.01.007

Cited by 4 publications

(2 citation statements)

References 58 publications

(84 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the strength of the applied field increased, the linear correlation between the magnetization and the applied magnetic field in the sample indicated paramagnetism. The paramagnetic character of these Gd 2 O 3 @PEG nanoparticles is commonly shared by positive contrast agents for magnetic resonance imaging (MRI) [48,49]. The slope of the M-H curve corresponds to a susceptibility, j, of 8.2 Â 10 À5 which is greater than the susceptibility of PEG-coated Gd 2 O 3 :Er 3+ nanoparticles (j = 2.0 Â 10 À5 ) [29].…”

Section: Resultsmentioning

confidence: 99%

A simple straightforward thermal decomposition synthesis of PEG-covered Gd 2 O 3 (Gd 2 O 3 @PEG) nanoparticles

Ahab

Rohman

Iskandar

et al. 2016

Advanced Powder Technology

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

A simple straightforward thermal decomposition synthesis of PEG-covered Gd 2 O 3 (Gd 2 O 3 @PEG) nanoparticles

Ahab

Rohman

Iskandar

et al. 2016

Advanced Powder Technology

View full text Add to dashboard Cite

“…These are called ‘positive contrast agents.’ SPM NPs increase the transverse relaxation rate by producing magnetic field inhomogeneities in their surroundings. Whereas specific MRI sequences can produce positive contrast with SPM NPs, SPM NPs appear dark in conventional MRI sequences, therefore, they belong in the negative CA category. Compared to gadolinium compounds, SPM NPs have the advantage of bearing a huge magnetic moment which produces a large dipolar magnetic field and of being non‐toxic in the current state of knowledge.…”

mentioning

confidence: 99%

Magnetic resonance relaxation induced by superparamagnetic particles used as contrast agents in magnetic resonance imaging: a theoretical review

Vuong

Gillis

Roch

et al. 2017

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Superparamagnetic nanoparticles are used as contrast agents in magnetic resonance imaging and allow, for example, the detection of tumors or the tracking of stem cells in vivo. By producing magnetic inhomogeneities, they influence the nuclear magnetic relaxation times, which results in a darkening, on the image, of the region containing these particles. A great number of studies have been devoted to their magnetic properties, to their synthesis and to their influence on nuclear magnetic relaxation. The theoretical and fundamental understanding of the behavior of these particles is a necessary step in predicting their efficiency as contrast agents, or to be able to experimentally obtain some of their properties from a nuclear magnetic resonance measurement. Many relaxation models have been published, and choosing one of them is not always easy, many parameters and conditions have to be taken into account. Relaxation induced by superparamagnetic particles is generally attributed to an outersphere relaxation mechanism. Each model can only be used under specific conditions (motional averaging regime, static regime, high magnetic field, etc.) or for a particular sequence (Carr-Purcell-Meiboom-Gill, spin echo, free-induction decay, nuclear magnetic relaxation dispersion profile, etc.). The parameters included in the equations must be carefully interpreted. In some more complex conditions, simulations are necessary to be able to predict the relaxation rates. A good agreement is usually observed between the theoretical predictions and the experimental results, although some data still cannot be fully understood, such as the dependence of the transverse relaxation on the magnetic field. WIREs Nanomed Nanobiotechnol 2017, 9:e1468. doi: 10.1002/wnan.1468 For further resources related to this article, please visit the WIREs website.

show abstract

Phantom gels towards medicine improvement: uses for magnetic device tests and enhancements on magnetic-dependent clinical techniques

Sánchez

Arciniegas

Álvarez

et al. 2019

Materials for Biomedical Engineering

View full text Add to dashboard Cite

Theoretical and experimental study of ON-Resonance Saturation, an MRI sequence for positive contrast with superparamagnetic nanoparticles

Cited by 4 publications

References 58 publications

A simple straightforward thermal decomposition synthesis of PEG-covered Gd 2 O 3 (Gd 2 O 3 @PEG) nanoparticles

A simple straightforward thermal decomposition synthesis of PEG-covered Gd 2 O 3 (Gd 2 O 3 @PEG) nanoparticles

Magnetic resonance relaxation induced by superparamagnetic particles used as contrast agents in magnetic resonance imaging: a theoretical review

Phantom gels towards medicine improvement: uses for magnetic device tests and enhancements on magnetic-dependent clinical techniques

Contact Info

Product

Resources

About