Theoretical and experimental study of fluid behavior of a peristaltic micropump

Na, Sangkwon; Ridgeway, S.; Cao, Li

doi:10.1109/ugim.2003.1225751

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…Mechanical pumps, typically employing actuated compliant diaphragms, can handle a large variety of fluids but often involve complicated structures (e.g., as required by check valves) and present integration challenges. Peristaltic micropumps [4][5][6][7][8][9], however, are a class of mechanical pumps that are relatively simple in structure and amenable to miniaturization and integration. In such devices, a series of diaphragms are actuated in sequence in a manner emulating wave-like muscle contractions of a tube-shaped organ, resulting in forward motion of fluids.…”

Section: Introductionmentioning

confidence: 99%

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

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This paper presents lumped-parameter simulation of dynamic characteristics of peristaltic micropumps. The pump consists of three pumping cells connected in series, each of which is equipped with a compliant diaphragm that is electrostatically actuated in a peristaltic sequence to mobilize the fluid. Diaphragm motion in each pumping cell is first represented by an effective spring subjected to hydrodynamic and electrostatic forces. These cell representations are then used to construct a system-level model for the entire pump, which accounts for both cell-and pump-level interactions of fluid flow and diaphragm vibration. As the model is based on first principles, it can be evaluated directly from the device's geometry, material properties and operating parameters without using any experimentally identified parameters. Applied to an existing pump, the model correctly predicts trends observed in experiments. The model is then used to perform a systematic analysis of the impact of geometry, materials and pump loading on device performance, demonstrating its utility as an efficient tool for peristaltic micropump design.

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Section: Introductionmentioning

confidence: 99%

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

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show abstract

“…The testing results indicate that our type of actuator diaphragm offers a significant advantage over the conventional ones; increased displacement-several times that of a geometrically equivalent unimorph and bimorph-type actuators. From the experimental results, the present micropump could generate a flow rate up to 900µl/min with only 160 Vp-p (voltage peak to peak) applied voltage and 60 Hz frequency, higher than those of the previously developed peristaltic micropumps [11][12][13][14][15]. Finally, we have investigated the power consumption aspects of the developed micropump.…”

Section: Introductionmentioning

confidence: 91%

Development of a Peristaltic Micropump for Bio-Medical Applications Based on Mini LIPCA

2008

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This paper presents the design, fabrication, and experimental characterization of a peristaltic micropump. The micropump is composed of two layers fabricated from polydimethylsiloxane (PDMS) material. The first layer has a rectangular channel and two valve seals. Three rectangular mini lightweight piezo-composite actuators are integrated in the second layer, and used as actuation parts. Two layers are bonded, and covered by two polymethyl methacrylate (PMMA) plates, which help increase the stiffness of the micropump. A maximum flow rate of 900 µl/min and a maximum backpressure of 1.8 kPa are recorded when water is used as pump liquid. We measured the power consumption of the micropump. The micropump is found to be a promising candidate for bio-medical application due to its bio-compatibility, portability, bidirectionality, and simple effective design.

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“…A piezoelectric ceramic actuator disc and two titanium fluid connectors are hermetically bonded to the chip 64 An IDDS that uses three embedded piezoelectric transducer actuators to drive the three micropump chambers in a peristaltic motion 65 A 70 mm × 35 mm × 1.63 mm peristaltic micropump designed and fabricated using DRIE, anodic bonding, radio frequency sputtering, and oxidation/deposition, that can deliver drug solution at 10 µL/min 66…”

Section: Implantable Mems‐based Drug Delivery Systems: Platformsmentioning

confidence: 99%

“…An IDDS that uses three embedded piezoelectric transducer actuators to drive the three micropump chambers in a peristaltic motion 65…”

Section: Implantable Mems‐based Drug Delivery Systems: Platformsmentioning

confidence: 99%

Microchips and controlled‐release drug reservoirs

Staples¹

2010

WIREs Nanomed Nanobiotechnol

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This review summarizes and updates the development of implantable microchip-containing devices that control dosing from drug reservoirs integrated with the devices. As the expense and risk of new drug development continues to increase, technologies that make the best use of existing therapeutics may add significant value. Trends of future medical care that may require advanced drug delivery systems include individualized therapy and the capability to automate drug delivery. Implantable drug delivery devices that promise to address these anticipated needs have been constructed in a variety of ways using micro- and nanoelectromechanical systems (MEMS or NEMS)-based technology. These devices expand treatment options for addressing unmet medical needs related to dosing. Within the last few years, advances in several technologies (MEMS or NEMS fabrication, materials science, polymer chemistry, and data management) have converged to enable the construction of miniaturized implantable devices for controlled delivery of therapeutic agents from one or more reservoirs. Suboptimal performance of conventional dosing methods in terms of safety, efficacy, pain, or convenience can be improved with advanced delivery devices. Microchip-based implantable drug delivery devices allow localized delivery by direct placement of the device at the treatment site, delivery on demand (emergency administration, pulsatile, or adjustable continuous dosing), programmable dosing cycles, automated delivery of multiple drugs, and dosing in response to physiological and diagnostic feedback. In addition, innovative drug-medical device combinations may protect labile active ingredients within hermetically sealed reservoirs.

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Theoretical and experimental study of fluid behavior of a peristaltic micropump

Cited by 8 publications

References 5 publications

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Development of a Peristaltic Micropump for Bio-Medical Applications Based on Mini LIPCA

Microchips and controlled‐release drug reservoirs

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