Theoretical Analysis of Oxygen Supply to Contracted Skeletal Muscle

Groebe, Karlfried; Thews, G.

doi:10.1007/978-1-4684-5188-7_62

Cited by 37 publications

(25 citation statements)

References 39 publications

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“…Based on direct measurements of intracellular Po2 (28) and mathematical modeling (29) in maximally exercising muscle, previous analyses of diffusivity, not knowing PMITOO2, have limited their calculations to Vo2n,, where it was assumed cellular Po2 was very low ( 1-3 mmHg range) and so could be neglected (4,6,30,31). The present study has demonstrated that the assumption of a low intracellular P02 at V02m,., relied upon in these initial investigations, was valid and in fact is the case even at submaximal exercise intensities eliciting only 50% of VO2max (Fig.…”

Section: Discussionmentioning

confidence: 99%

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.

Richardson¹,

Noyszewski²,

Kendrick³

et al. 1995

J. Clin. Invest.

544

527

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Section: Discussionmentioning

confidence: 99%

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.

Richardson¹,

Noyszewski²,

Kendrick³

et al. 1995

J. Clin. Invest.

544

527

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“…Many models for oxygen transport from blood into tissue have been investigated [1][2][3][4][5][6][7], but they are mainly concerned with steady state and do not allow for transient solutions. Also, the models are over-simplified and neglect certain critical aspects of the oxygen transport system.…”

Section: Introductionmentioning

confidence: 99%

A computational model of oxygen transport from red blood cells to mitochondria

Beyer¹,

Bassingthwaighte

Deußen

2002

Computer Methods and Programs in Biomedicine

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A computational model of oxygen transport from red blood cells to mitochondria with subsequent reaction to water is presented. This computational model consists of a five region convectiondiffusion-reaction mathematical model which is solved using a standard numerical time-split method. The unique feature of this mathematical model is the treatment of the red blood cells and the plasma as two separate flows. The numerical method is second order accurate overall. This computational model is useful for analyzing residue data from positron emission tomography or data from multiple indicator dilution curves.

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“…A model to describe the intracellular Po2 distribution based on these authors' results was developed by Groebe & Thews (1986) assuming a maximum extracellular PO of about 30 mmHg and thus large diffusion gradients between the red blood cells and the interior of the muscle fibre. Their model demonstrated that, despite low levels of PO , the distribution of oxygen within the cell remained homogeneous due to facilitateA diffusion and the 02 buffering power of myoglobin.…”

Section: Discussionmentioning

confidence: 99%

Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits.

Harrison

Birkenhake

Knauf

et al. 1990

The Journal of Physiology

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2. In a further model, the analysis of hydrogen clearance curves measured in the femoral vein using intravascular needle electrodes in rabbits enabled the distribution of blood flow to be evaluated both under resting conditions and during direct 2 Hz stimulation of the vastus medialis muscle.3. Increased oxygen consumption, induced by stimulation, caused increases in capillary flow which were not necessarily accompanied by augmentation of femoral artery flow.4. Po2 histograms provided no evidence of cellular anoxia even at the maximum level of oxygen consumption.5. A two-compartment distribution of flow was measured under resting conditions, whereas only one compartment could be resolved during 2 Hz stimulation of the vastus medialis muscle in the rabbit experiments. A clear redistribution of flow was observed in the absence of any increase in total flow. 6. A model for oxygen-dependent regulation of capillary blood flow involving high-flow and normal-flow compartments is proposed.

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Theoretical Analysis of Oxygen Supply to Contracted Skeletal Muscle

Cited by 37 publications

References 39 publications

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.

A computational model of oxygen transport from red blood cells to mitochondria

Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits.

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