Theoretical analysis and verification of ultrasound displacement and strain imaging

Skovoroda, A.R.; Emelianov, Stanislav; Lubinski, M.A.; Sarvazyan, Armen; O’Donnell, Matthew

doi:10.1109/58.285463

Cited by 144 publications

(73 citation statements)

References 21 publications

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“…The concept of "strain filter" has been used to determine the theoretical bound of SNR e at different levels of strain, which corresponds to the tightest bound of noise in strain estimation [42]. This bound consists of several segments as described in Eq.…”

Section: Theoretical Analysis Of the Signal-to-noise Ratio Inmentioning

confidence: 99%

“…The signal-to-noise ratio (SNR) of ultrasound elastography has been extensively studied in the past [40][41][42][43][44]. It has been shown that the strain image SNR is dependent on the strain levels, system characteristics (e.g., transducer center frequency and bandwidth), as well as signal processing parameters (e.g., kernel size) [41,44].…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonic Measurement of Scleral Cross-Sectional Strains During Elevations of Intraocular Pressure: Method Validation and Initial Results in Posterior Porcine Sclera

Tang

Liu

2012

Journal of Biomechanical Engineering

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Background. Scleral biomechanical properties may be important in the pathogenesis and progression of glaucoma. The goal of this study is to develop and validate an ultrasound method for measuring cross-sectional distributive strains in the sclera during elevations of intraocular pressure (IOP). Method of Approach. Porcine globes (n ¼ 5) were tested within 24 hs postmortem. The posterior scleral shells were dissected and mounted onto a custom-built pressurization chamber. A high-frequency (55-MHz) ultrasound system (Vevo660, VisualSonics Inc., Toronto) was employed to acquire the radio frequency data during scans of the posterior pole along both circumferential and meridian directions. The IOP was gradually increased from 5 to 45 mmHg. The displacement fields were obtained from correlation-based ultrasound speckle tracking. A least-square strain estimator was used to calculate the strains in both axial and lateral directions. Experimental validation was performed by comparing tissue displacements calculated from ultrasound speckle tracking with those induced by an actuator. Theoretical analysis and simulation experiments were performed to optimize the ultrasound speckle tracking method and evaluate the accuracy and signal-to-noise ratio (SNR) in strain estimation. Results. Porcine sclera exhibited significantly larger axial strains (e.g., À5.1 6 1.5% at 45 mmHg, meridian direction) than lateral strains (e.g., 2.2 6 0.7% at 45 mmHg, meridian direction) during IOP elevations (P's < 0.01). The strain magnitudes increased nonlinearly with pressure increase. The strain maps displayed heterogeneity through the thickness. The lateral strains were significantly smaller in the circumferential direction than the meridian direction at 45 mmHg (P < 0.05). Experimental validation showed that the ultrasound speckle tracking method was capable of tracking displacements at the accuracy of sub-micron to micron. Theoretical analysis predicted the dependence of the strain estimation SNR on the strain level, as well as signal processing parameters such as kernel size. Simulation results showed that ultrasound speckle tracking had a high accuracy for estimating strains of 1-5% and a high SNR for strains of 0.5-5%. Conclusions. A new experimental method based on ultrasound speckle tracking has been developed for obtaining cross-sectional strain maps of the posterior sclera. This method provides a useful tool to examine distributive strains through the thickness of the sclera during elevations of IOP.

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Section: Theoretical Analysis Of the Signal-to-noise Ratio Inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasonic Measurement of Scleral Cross-Sectional Strains During Elevations of Intraocular Pressure: Method Validation and Initial Results in Posterior Porcine Sclera

Tang

Liu

2012

Journal of Biomechanical Engineering

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“…Die Entwicklung neuer Bildgebungsverfahren zur Darstellung zusätzlicher Gewebe- [7]. Nachteil der sonographischen Elastographie ist die Einschränkung der Darstellbarkeit auf zwei Raumdimensionen mit einer akzeptablen Auflösung nur in axialer Ausrichtung [8]. Diese Einschränkungen gelten für die MR-Elastographie nicht.…”

Section: Introductionunclassified

Darstellung von Tumoren der weiblichen Brust mit MR-Elastographie

Lorenzen

Sinkus²,

Schrader³

et al. 2001

Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr

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Schlüsselwörter: MR-Elastographie ± Brusttumor-Diagnostik ± GewebecharakterisierungImaging of breast tumors using MR-Elastography. Purpose:Imaging of breast tumors using MR-Elastography. Material and method: Low-frequency mechanical waves are transmitted into breast-tissue by means of an oscillator. The local characteristics of the mechanical wave are determined by the elastic properties of the tissue. By means of a motion-sensitive spinecho-sequence these waves can be displayed within the phase of the MR image. Subsequently, these images can be used to reconstruct the local distribution of elasticity. In-vivo measurements were performed in 3 female patients with malignant tumors of the breast. Results: All patients tolerated the measurement set-up without any untoward sensation in the contact area of skin and oszillator. The waves completely penetrated the breast, encompassing the axilla and regions close to the chest wall. All tumors were localized by MRE as structures of markedly stiffer tissue when compared to the surrounding tissue. Furthermore, in one patient, a metastasis in an axillary lymph node was detetected. In all patients, local regions of increased elasticity were found in the remaining parenchyma of the breast, which, however, did not reach the high levels of elasticity found in the tumors. Conclusion: MRE is an imaging modality enabling adjunct tissue differentiation of mammary tumors.

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“…From the initial 3-D Young's modulus map, an approximate plane of symmetry containing the lesion can be identified, and acousto-mechanical deformation experiment is performed in this plane. As described previously [Skovoroda et al 1994 and, accurate and direct (i.e., without any assumptions) absolute 3-D elasticity reconstruction can be performed in this plane combining internal strain and surface stress measurements.…”

Section: *+Je(e(^ff-mentioning

confidence: 99%

“…Suice this elasticity imagmg approach assumes a straightforward model such as this, reconstruction in the vicinity of the lesion is far less susceptible to noise. We have already developed [Skovoroda et al 1994;Sarvazyan and Skovoroda 1996;Skovoroda and Sarvazyan 1999] and successfiilly applied the model-based reconstruction approach to study elasticity imaging ], This model is based on general theory of elasticity for incompressible medium. Indeed, most soft tissues are incompressible materials with Poisson's ratio approaches 0.5 [Sarvazyan et al 1995].…”

Section: Stress and Strain Imagingmentioning

confidence: 99%

Acousto-Mechanical Imaging for Breast Cancer Detection

Emelianov¹

2003

PsycEXTRA Dataset

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Theoretical analysis and verification of ultrasound displacement and strain imaging

Cited by 144 publications

References 21 publications

Ultrasonic Measurement of Scleral Cross-Sectional Strains During Elevations of Intraocular Pressure: Method Validation and Initial Results in Posterior Porcine Sclera

Ultrasonic Measurement of Scleral Cross-Sectional Strains During Elevations of Intraocular Pressure: Method Validation and Initial Results in Posterior Porcine Sclera

Darstellung von Tumoren der weiblichen Brust mit MR-Elastographie

Acousto-Mechanical Imaging for Breast Cancer Detection

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