Theophylline-Loaded Compritol Microspheres Prepared by Ultrasound-Assisted Atomization

Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

“…In the diffractogram of the physical mixture, the characteristic peaks of Compritol ® were present at 21.27° 2θ and at 23.35° 2θ, confirming its crystallinity and presence in β' form, as previously suggested by DSC results. 43 The crystalline peaks of SL at 16.01, 16.67, and 17.29° 2θ were evident but with lower intensities in the physical mixture, confirming the presence of SL in crystalline form. On the contrary, the diffractogram of SL-NLC formulation showed a deformed peak for SL, signifying that the drug lost its crystallinity and was transformed to an amorphous state or molecular dispersion within the nanocarriers.…”

Hot-melts in buccoadhesive patches: An approach for bioavailability enhancement of highly-metabolized drugs with short elimination half-life

“…Drug content (%w/w ± SD) Thickness (mm ± SD) Amount of mucin adsorbed per patch total surface area (mcg/cm 2 A C18 column Inertsil Ò ODS-3, 5 lm, 150 Â 4.6 mm (Japan) was used for the chromatographic separation. The analysis was performed at the multiple reaction monitoring mode (MRM) [20].…”

“…The molten mass was rapidly cooled over an ice bath and allowed to solidify. The solidified mass was pulverized in a mortar then sieved through 0.5 lm sieve [2,4].…”

“…Hot-melts are prepared by melting a physical mixture of the drug and a carrier, followed by sudden cooling of the molten mass, pulverization and sieving [2,3]. Hot-melts can be used as a maneuver to control drug release if prepared with a water insoluble carrier, such as Compritol 888 ATO.…”

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“…The methods commonly used in microsphere preparation include emulsion method 8 , phase separation method 9 , spray drying method 10 , ultrasonic atomization method 11 , electrospray method 12 , and microfluidic method 13 . Among the above-mentioned methods, spray drying method is most widely used in manufacture scale and the emulsion methods are commonly accepted in laboratory level.…”