“…Finally, Lim et al [3] reported that theophylline reduced the number of eosinophils in sputa, biopsied specimens, and bronchoalveolar lavage fluids in mild asthmatic patients. Theophylline actually possesses a variety of in vitro effects on human eosinophils: induction of apoptosis [4, 5], inhibition of degranulation [5,6,7] and cell migration [8], and reduction of the surface expression of CD11b [6, 7, 9] or CD4 [8]. In this context, we have reported that theophylline attenuates eosinophil adhesion to endothelial cells in vitro at a clinically therapeutic concentration [9].…”