Theophylline and the immune response: In vitro and in vivo effects

Scordamaglia, A; Ciprandi, Giorgio; Ruffoni, S; Caria, Maria; Paolieri, F.; Venuti, D.; Canonica, Giorgio Walter

doi:10.1016/0090-1229(88)90087-6

Cited by 49 publications

(19 citation statements)

References 8 publications

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“…nifedipine and verapamil) (22, 23, Morgano et al submitted), theophylline (1,32), ranitidine (9, 28) glucocorticosteroids (14,33) and adrenergic agents (15,24,25,36) on the immune system. Since these pharmacological compounds suppress the immune response (even in vivo), these drugs should be used with caution in patients with infections or with disorders of the immune response.…”

Section: Resultsmentioning

confidence: 99%

“…Our studies have further shown the theophylline inhibition of the immune response to be dose dependent, and more sophisticated experiments indicate that the "once a day" administration of theophylline (35), should be warmly advocated (12,32).…”

Section: G W Canonica and G Ciprandimentioning

confidence: 99%

“…Our experimental procedures will not be described in this review as they have been previously reported (3,4,6,7,32).…”

Section: Experimental Evidencementioning

confidence: 99%

“…However, since previous studies have shown interaction between glucocorticosteroids, theophylline, ketotifen, or adrenergic agents and the immune system (1,9,11,12,24,26,27,32), we considered it useful to investigate the possible effects of other compounds employed in these disorders in order to obtain additional experimental data concerning these same drugs and, consequently, their proper clinical use.…”

mentioning

confidence: 99%

“…We recently demonstrated that cromolyn (4), ketotifen (6) and theophylline (10,32), commonly used in the treatment of allergic syndromes, can interfere with the in vitro immune response, whereas oxatomide (7), fenoterol (8) and astemizole (manuscript in preparation) do not. In addition, we have studied two drugs with cytoprotective activity i.e.…”

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confidence: 99%

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Antiallergic drugs and the immune response

Canonica

Ciprandi

1989

Allergy

Self Cite

112

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Re V. MSince the pharmacological treatment of allergic diseases is used in patients with alteration of the immune response due to atopy and possible concomitant infections, we have investigated the possible effects of such drugs as cromolyn, theophylline, ketotifen, oxatomide, astemizole, fenoterol, pirenzepine, and rosaprostol on the in vitro immune response, in order to obtain experimental data and, as a consequence, clinical conclusions. In a series of investigations by our group and other authors the following immunological parameters have been considered: T cell activation induced by different pathways (i.e. autologous stimulation, PHA, anti-CD3, -CD2 and -CD28 monoclonal antibodies), and lymphokine production (i.e. IL-1, IL-2 and gamma-IFN). For a more detailed experimental model the experiments have been performed both in bulk culture and by using T cell clones derived from the peripheral blood. The results show cromolyn to have an enhancing effect, theophylline and ketotifen a suppressing effect, whereas the remainder show no effect on the immune response. These data are considered and discussed from the aspect of their possible clinical relevance and also in light of the in vivo data previously reported.

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