Theophylline and Salbutamol Improve Pulmonary Function in Patients with Irreversible Chronic Obstructive Pulmonary Disease

Thomas, Peter D. G.; Pugsley, John; Stewart, John H.

doi:10.1378/chest.101.1.160

Cited by 49 publications

(31 citation statements)

References 14 publications

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“…This small increase is of doubtful clinical significance. Larger clinical studies have demonstrated that theophylline increases FEV 1 (22,35,36), with the greater increases being in longer studies and those where plasma theophylline levels exceeded 12 mg/L. However, there are limitations to the use of FEV 1 as a method of assessing clinical improvement with drug therapy.…”

Section: Discussionmentioning

confidence: 99%

Effect of Theophylline on Induced Sputum Inflammatory Indices and Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease

Culpitt

Matos

Russell

et al. 2002

Am J Respir Crit Care Med

167

113

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Chronic obstructive pulmonary disease (COPD) is characterized by a neutrophilic airway inflammation that can be demonstrated by examination of induced sputum. Theophylline has antiinflammatory effects in asthma, and in the present study we investigated whether a similar effect occurs in COPD patients treated with low doses of theophylline. Twenty-five patients with COPD were treated with theophylline (plasma level of 9-11 mg/L) for 4 weeks in a placebo-controlled, randomized, double-blind crossover study. Theophylline was well tolerated. Induced sputum inflammatory cells, neutrophils, interleukin-8, myeloperoxidase, and lactoferrin were all significantly reduced by about 22% by theophylline. Neutrophils from subjects treated with theophylline showed reduced chemotaxis to N-formyl-met-leu-phe (approximately 28%) and interleukin-8 (approximately 60%). Neutrophils from a healthy donor showed reduced chemotaxis (approximately 30%) to induced sputum samples obtained during theophylline treatment. These results suggest that theophylline has antiinflammatory properties that may be useful in the long-term treatment of COPD.

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Section: Discussionmentioning

confidence: 99%

Effect of Theophylline on Induced Sputum Inflammatory Indices and Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease

Culpitt

Matos

Russell

et al. 2002

Am J Respir Crit Care Med

167

113

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“…Theophylline in combination with beta-2-agonists improves dyspnea more than theophylline monotherapy [58]. In a study by Thomas et al [59], theophylline plus salbutamol significantly improves FEV 1 by 31.3% compared to only 13.5 and 16.2% with the monotherapies respectively. However, theophylline combined with beta-2-agonists is non-superior to the use of beta-2-agonists alone [58].…”

Section: Methylxanthinesmentioning

confidence: 99%

Diagnosis, Prevention and Treatment of Stable COPD and Acute Exacerbations of COPD: The Swiss Recommendations 2018

et al. 2018

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The Swiss National Guidelines 2013 for chronic obstructive pulmonary disease have been revised in order to acknowledge recent progress in diagnosis and management of this disease. The resulting new Swiss recommendations are based on best evidence from the literature, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2018 report and other published national guidelines. Misdiagnosis of chronic obstructive pulmonary disease is common and means that patients do not always receive optimal treatment. To improve the management of patients with chronic obstructive pulmonary disease in Switzerland, these recommendations encourage a more comprehensive assessment of patients, based on the combined assessment of symptoms, degree of airflow limitation, risk of exacerbation and the presence of comorbidities. Recommendations for evidence-based preventive measures, as well as pharmacological and non-pharmacological strategies for the management of both stable and acute exacerbations of chronic obstructive pulmonary disease are provided in this update.

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“…8 Therefore, a lower target range of 8 to 13 mg/dL is safer and results in improvements in FEV 1 , dyspnea, and health status. 8,31,32 The combination of 2 or more bronchodilators (theophylline, albuterol, and ipratropium) has some logical rationale, as they seem to have additive effects (mean improvement of close to 30%) and can result in maximum benefit in stable COPD. 31,32 Corticosteroids and Anti-inflammatory Agents.…”

Section: Pharmacological Therapymentioning

confidence: 99%

“…8,31,32 The combination of 2 or more bronchodilators (theophylline, albuterol, and ipratropium) has some logical rationale, as they seem to have additive effects (mean improvement of close to 30%) and can result in maximum benefit in stable COPD. 31,32 Corticosteroids and Anti-inflammatory Agents. In contrast to asthma management, the role of anti-inflammatory drugs in stable COPD remains a matter of debate.…”

Section: Pharmacological Therapymentioning

confidence: 99%

A 62-Year-Old Woman With Chronic Obstructive Pulmonary Disease

Celli

2003

JAMA

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Theophylline and Salbutamol Improve Pulmonary Function in Patients with Irreversible Chronic Obstructive Pulmonary Disease

Cited by 49 publications

References 14 publications

Effect of Theophylline on Induced Sputum Inflammatory Indices and Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease

Effect of Theophylline on Induced Sputum Inflammatory Indices and Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease

Diagnosis, Prevention and Treatment of Stable COPD and Acute Exacerbations of COPD: The Swiss Recommendations 2018

A 62-Year-Old Woman With Chronic Obstructive Pulmonary Disease

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