Theme issue on infections and safety—An introduction

Scobie, Linda; Denner, Joachim

doi:10.1111/xen.12447

Cited by 3 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The two deaths were because of porcine cytomegalovirus (PCMV) infection, a complication that could have been avoided through the use of PCMV-negative donors. Therefore, it will be important to use pathogen-free animals in future [46,55]. In DPF-environments, infection avoidance is achieved primarily through good animal husbandry, and selecting Workstreams within the TLJ project help to achieve the primary aim of ESOTto improve patient access to (and outcomes in) transplantation.…”

Section: Minimizing Infection Riskmentioning

confidence: 99%

Organ transplants of the future: planning for innovations including xenotransplantation

et al. 2021

Self Cite

View full text Add to dashboard Cite

The future clinical application of animal-to-human transplantation (xenotransplantation) is of importance to society as a whole. Favourable preclinical data relevant to cell, tissue and solid organ xenotransplants have been obtained from many animal models utilizing genetic engineering and protocols of pathogen-free husbandry. Findings have reached a tipping point, and xenotransplantation of solid organs is approaching clinical evaluation, the process of which now requires close deliberation. Such discussions include considering when there is sufficient evidence from preclinical animal studies to start first-in-human xenotransplantation trials. The present article is based on evidence and opinions formulated by members of the European Society for Organ Transplantation who are involved in the Transplantation Learning Journey project. The article includes a brief overview of preclinical concepts and biology of solid organ xenotransplantation, discusses the selection of candidates for first-in-human studies and considers requirements for study design and conduct. In addition, the paper emphasizes the need for a regulatory framework for xenotransplantation of solid organs and the essential requirement for input from public and patient stakeholders.

show abstract

Section: Minimizing Infection Riskmentioning

confidence: 99%

Organ transplants of the future: planning for innovations including xenotransplantation

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…This past issue in Xenotransplantation provide readers with a number of strategies to evaluate, quantify, and eliminate such risks. Scobie and Denner provides their commentary to introduce the issue by pointing out noteworthy pieces of each article.…”

Section: Introductionmentioning

confidence: 99%

Xenotransplantation literature update, July/August 2018

Levy

Burlak

2018

Xenotransplantation

View full text Add to dashboard Cite

Recent progress in porcine islet isolation, culture and engraftment strategies for xenotransplantation

Kemter

Wolf²

2018

Current Opinion in Organ Transplantation

View full text Add to dashboard Cite

Purpose of review Xenotransplantation of porcine islets is a realistic option to restore β-cell function in type 1 diabetic patients. Among other factors, such as islet donor age (fetal, neonatal and adult) and genotype (wild type and genetically modified), choice of the transplantation site, and immune protection of the islets, efficient strategies for islet isolation, culture and engraftment are critical for the success of islet xenotransplantation. Recent findings Neonatal porcine islets (NPIs) are immature at isolation and need to be matured in vitro or in vivo before they become fully functional. Recent developments include a scalable protocol for isolation of clinically relevant batches of NPIs and a stepwise differentiation protocol for directed maturation of NPIs. In addition, different sources of mesenchymal stem cells were shown to support survival and functional maturation of NPIs in vitro and in various transplantation models in vivo. Summary A plethora of different culture media and supplements have been tested; however, a unique best culture system for NPIs is still missing. New insights, for example from single-cell analyses of islets or from stem cell differentiation toward β cells may help to optimize culture of porcine islets for xenotransplantation in an evidence-based manner.

show abstract

Theme issue on infections and safety—An introduction

Cited by 3 publications

References 18 publications

Organ transplants of the future: planning for innovations including xenotransplantation

Organ transplants of the future: planning for innovations including xenotransplantation

Xenotransplantation literature update, July/August 2018

Recent progress in porcine islet isolation, culture and engraftment strategies for xenotransplantation

Contact Info

Product

Resources

About