Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis

Maity, Swapna; Ukil, Anindita; Karmakar, Shilpi; Datta, Neeta; Chaudhuri, T. C.; Vedasiromoni, J. R.; Ganguly, Dilip; Das, Pritha

doi:10.1016/s0014-2999(03)01760-6

Cited by 56 publications

(44 citation statements)

References 41 publications

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“…Furthermore, its five active constituents (paeoniflorin, jujubogenin, jujuboside A, 1,8-cineol, and cinnamaldehyde) were also found to significantly inhibit FMLP-induced neutrophil chemotaxis dosedependently, whereas GR and diammonium glycyrrhizinate did not. So, the inhibitory effects of GJT on FMLP-induced neutrophil chemotaxis and MPO activity in inflamed colon tissue suggest that the anti-inflammatory activity of GJT is due to its inhibition of leukocyte migration into inflamed tissues (Nast and LeDuc, 1988;Maity et al, 2003). In terms of the spasmolytic activity induced by inhibiting isometric tension (IC 50 ) in mouse ileum by electric stimulation, aqueous extracts of GR, PR, and ZF were found to have more spasmolytic activity than CR and ZR.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis

Lee

Kang

Park

et al. 2009

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis

Lee

Kang

Park

et al. 2009

Journal of Ethnopharmacology

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“…In some parts of East Asia, aerobic and anaerobic microbial fermentation is applied to green tea or boiled tea leaves to produce tea products, which also decrease catechin concentrations. Although the importance of catechin degradation products has been reported recently, [2][3][4] little is known about the chemistry of products in fermented tea because of their complexity. Our research group has reported studies of enzymatic oxidation of catechins in black tea production [5][6][7] and hydrogenation of catechins in anaerobic microbial fermentation of green tea.…”

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confidence: 99%

Theagalloflavic Acid, a New Pigment Derived from Hexahydroxydiphenoyl Group, and Lignan Oxidation Products Produced by Aerobic Microbial Fermentation of Green Tea

Matsuo

Matsuda

Sugihara

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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Chinese ripe pu-erh tea is produced by aerobic microbial fermentation of green tea. To clarify the microbial degradation of tea polyphenols, Japanese commercial green tea was mixed with Chinese ripe puerh tea, which retains microorganisms, and fermented for 5 d. Chromatographic separation yielded a novel water-soluble yellow pigment termed theagalloflavic acid. Spectroscopic and chemical evidence suggested that this pigment was produced by oxidative ring cleavage of hexahydroxydiphenoyl esters. In addition, two new oxygenated lignin metabolites, ( )-5,5′-dihydroxypinoresinol and 5-hydroxydihydrodehydrodiconiferyl alcohol, were also isolated together with known degradation products of quercetin and tea catechins.

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“…Several flavonoids have anti-inflammatory properties via inhibition of NO production [8,20] or NF-B activation [31]. Furthermore, most flavonoids inhibit histamine release, so they are excellent candidates for clinical studies to treat or prevent allergic diseases.…”

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confidence: 99%

Orally Administered Rutin Inhibits the Gene Expression of Th2 Cytokines in the Gut and Lung in Aged Mice

Morimoto

Takagi

Higashi

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Rutin is one of the flavonoids derived from plants such as buckwheat and is well known as a powerful antioxidant. To determine whether dietary rutin could modulate mucosal immunity, we examined the gene expression of Th1/Th2 cytokines and the receptors in the gut and lung. Aged (18 months old, 18 M) C3H/HeN female mice were orally administered rutin for 10 days. The small intestine and lung were taken and analyzed by real-time PCR for gene expression. Interleukin (IL)-13 and IL-13R2 gene expression was significantly low (P<0.05 respectively) in the small intestine of aged rutin-fed mice. Meanwhile, there was no change in interferon  gene expression between control and rutin-fed mice. IL-13 gene expression was also downregulated in the lung. To examine the mechanism of the inhibitory effect of rutin on Th2 cytokines in aged mice, intestinal nitric oxide synthase (NOS) expression was evaluated. Rutin inhibited inducible NOS (NOS2) gene expression, but not neuronal NOS and endothelial NOS. Gene analysis of cells collected from the small intestine by laser capture dissection revealed that NOS2 expression was significantly inhibited in crypt regions. Thus, rutin might be effective against a Th2-dominant profile through NOS2 inhibition in aged mice.

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Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis

Cited by 56 publications

References 41 publications

Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis

Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis

Theagalloflavic Acid, a New Pigment Derived from Hexahydroxydiphenoyl Group, and Lignan Oxidation Products Produced by Aerobic Microbial Fermentation of Green Tea

Orally Administered Rutin Inhibits the Gene Expression of Th2 Cytokines in the Gut and Lung in Aged Mice

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