Theanine attenuates hippocampus damage of rat cerebral ischemia-reperfusion injury by inhibiting HO-1 expression and activating ERK1/2 pathway

Zhao, Jing; Zhao, Xiayong; Tian, Junbin; Xue, Renyu; Luo, Bin; Lv, Jianrui; Gao, Jing; Wang, Mei

doi:10.1016/j.lfs.2019.117160

Cited by 21 publications

(7 citation statements)

References 34 publications

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“…In 2020, Zhao et al studied the exact molecular mechanism of the protective effect of cerebral ischemia/reperfusion (IR) injury and found that theanine had a protective effect on hippocampal injury in IR rats. This mechanism may also be related to inhibition of HO-1 expression and activation of the ERK1/2 reperfusion injury pathway, in addition to inhibition of oxidative stress [98]. (4) Effect on brain injury.…”

Section: Neuroprotective Effectsmentioning

confidence: 99%

Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology

et al. 2022

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Objectives Green tea (Camellia sinensis) is a kind of unfermented tea that retains the natural substance in fresh leaves to a great extent. It is regarded as the second most popular drink in the world besides water. In this paper, the phytochemistry, pharmacology, and toxicology of green tea are reviewed systematically and comprehensively. Key findings Green tea has been demonstrated to be good for human health. Nowadays, multiple pharmacologically active components have been isolated and identified from green tea, including tea polyphenols, alkaloids, amino acids, polysaccharides, and volatile components. Recent studies have demonstrated that green tea shows versatile pharmacological activities, such as antioxidant, anticancer, hypoglycemic, antibacterial, antiviral, and neuroprotective. Studies on the toxic effects of green tea extract and its main ingredients have also raised concerns including hepatotoxicity and DNA damage. Summary Green tea can be used to assist the treatment of diabetes, Alzheimer’s disease, oral cancer, and dermatitis. Consequently, green tea has shown promising practical prospects in health care and disease prevention.

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Section: Neuroprotective Effectsmentioning

confidence: 99%

Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology

et al. 2022

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“…In vivo, L-theanine, when ingested as a beverage, exists mainly in its free form and is metabolized to glutamic acid and ethylamine by glutaminases (Tsuge et al 2003). L-theanine has many bene cial effects, such as antioxidant, anticancer, and antiin ammatory effects, as well as protection of the cranial nerves (Li et al 2022;Deng et al 2016;Zhao et al 2020). Additionally, L-theanine exhibits anti-anxiety effects and improves sleep quality (Jang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine

Yamaura,

Sadamori,

Konishi

et al. 2023

Preprint

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L-theanine, an amino acid component of the tea leaves of Camellia sinensis, is sold in Japan as a supplement for good sleep. Although several studies in humans and mice have reported the effects of L-theanine on brain function, only a few reports have comprehensively clarified the disposition of theanine administered to mice and its effects on concentrations of other blood amino acids. In this study, we aimed to determine the changes in the blood levels of L-theanine administered to mice and amino acid composition of the serum. L-theanine were administered to four-week-old Std-ddY male mice orally or via tail vein injection. L-theanine and other amino acids in serum prepared from blood collected at different time points post-dose were labeled with phenylisothiocyanate and quantified. The serum concentration of orally administered L-theanine peaked 15 min after administration. The area under the curve for tail vein injection revealed the bioavailability of L- theanine to be approximately 70%. L-theanine administration did not affect any amino acid levels in the serum, but a significant increase in the peak area overlapping the Gly peak was observed 30 min after administration. L-theanine administered to mice was rapidly absorbed and eliminated, suggesting that taking L-theanine as a supplement is safe without affecting its own levels or serum levels of other amino acids. However, considering that Gly, similar to L-theanine, is used as a dietary supplement for its anxiolytic effects and to improve sleep, determining the effects of L-theanine administration on Gly is important and needs further research.

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“…It can be used as one of the significant indexes to estimate the freshness of tea ( 13 ). In addition, it has many health benefits, such as antioxidant, anti-inflammatory, neuroprotective, anti-cancer, anti-anxiety, metabolic regulatory, cardiovascular protective, liver and kidney protective, and immune regulatory effects ( 14 – 16 ). Due to its flavor and diverse health benefits, L-theanine has wide applications, such as being used as a beverage ingredient or dietary supplement ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis L.) With Multiple Health Benefits and Food Applications

Liu

et al. 2022

Front. Nutr.

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Tea (Camellia sinensis L.) is a very popular health drink and has attracted increasing attention in recent years due to its various bioactive substances. Among them, L-theanine, a unique free amino acid, is one of the most important substances in tea and endows tea with a special flavor. Moreover, L-theanine is also a bioactive compound with plenty of health benefits, including antioxidant, anti-inflammatory, neuroprotective, anticancer, metabolic regulatory, cardiovascular protective, liver and kidney protective, immune regulatory, and anti-obesity effects. Due to the unique characteristics and beneficial functions, L-theanine has potential applications in the development of functional foods. This review summarized the influencing factors of L-theanine content in teas, the main health benefits and related molecular mechanisms of L-theanine, and its applications in food, understanding of which can provide updated information for the further research of L-theanine.

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Theanine attenuates hippocampus damage of rat cerebral ischemia-reperfusion injury by inhibiting HO-1 expression and activating ERK1/2 pathway

Cited by 21 publications

References 34 publications

Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology

Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology

Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine

L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis L.) With Multiple Health Benefits and Food Applications

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