Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose

Theabrownin Alleviates Colorectal Tumorigenesis in Murine AOM/DSS Model via PI3K/Akt/mTOR Pathway Suppression and Gut Microbiota Modulation

“…Given that the study design was set as a treatment model, TB was provided only after the establishment of the AOM/DSS model, which might be too late in reversing the shortening in colon length and increase in DAI. The effect of TB with earlier administration on colitis related symptoms is yet to be explored in future studies, given its anti-inflammatory and antioxidative effects observed in previous studies [ 28 , 30 , 48 ].…”

“…TB has been proven to exert modulatory effects on gut microbiota and promote production of short chain fatty acids (SCFAs) in mice fed with high fat diet [ 26 , 27 ]. However, current studies have only focused on its prohibitory effects against hypercholesterolemia, hyperlipidemia, oxidative, gluconeogenesis, and other obesity-related metabolic dysfunctions [ 26 , 27 , 28 , 29 , 30 , 31 ].…”

Long-term administration of royal jelly regulates age-related disorders and improves gut function in naturally aging mice

“…6 Actually, drugs, lifestyle, and dietary habits are primary factors affecting the balance of the gut microbiota and this has been reported in human aging and mouse aging models. 6,51,52 A previous study showed that dietary RJ modulated the gut microbiota of healthy mice by decreasing harmful bacteria like Proteobacteria and Alistipes, while increasing beneficial bacteria like Lachnospiraceae_NK4A136_group, Bacteroides, and Prevotellaceae. 36 Meanwhile, Se-rich RJ exhibited superior regulatory effects on the gut microbiota and preferably promoted interactions between the gut microbiota and the host organism.…”

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

“…44,56 LPS was also proven to enhance the expression of SREBP-1c and Fasn and subsequently elevate liver steatosis and inflammatory response through the induction of TNF-α expression. 57 The microbiota-derived I3A or TA was further proven to decrease the secretion of LPS and the production of TNFα. 21,58 Therefore, the protective effects of FBT on dyslipidemia, hepatic steatosis and steatohepatitis in HFD-induced obese mice may be strongly associated with the altered gut microbiota and their metabolites.…”