2012
DOI: 10.1016/j.bcp.2012.08.011
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The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway

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Cited by 98 publications
(77 citation statements)
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“…This study found resveratrol not only disrupted Wnt signaling, but also abrogated Notch and STAT3 signaling. Although resveratrol inhibits the Wnt pathway, possibly by disrupting the β-catenin/TCF interaction (Figure 1 [Chen et al, 2012]), its mechanism may not be specific to cancer cells. When ingested by patients, resveratrol appeared to primarily target the normal colon mucosa (Nguyen et al, 2009a).…”
Section: Targeting the Wnt Pathwaymentioning
confidence: 99%
“…This study found resveratrol not only disrupted Wnt signaling, but also abrogated Notch and STAT3 signaling. Although resveratrol inhibits the Wnt pathway, possibly by disrupting the β-catenin/TCF interaction (Figure 1 [Chen et al, 2012]), its mechanism may not be specific to cancer cells. When ingested by patients, resveratrol appeared to primarily target the normal colon mucosa (Nguyen et al, 2009a).…”
Section: Targeting the Wnt Pathwaymentioning
confidence: 99%
“…20 The b-catenin/T-cell factor (TCF) complex may be a target of resveratrol in the Wnt/b-catenin signalling pathway. 21 In a recent study, Ozdemir et al 22 reported that resveratrol attenuated hyperoxia-induced lung injury in newborn rats, but the underlying mechanism has not been investigated and the results were incomplete. Based on the evidence described above, there is reason to hypothesize that resveratrol alleviates lung injury in hyperoxia-exposed neonatal rats via its antioxidative, anti-inflammatory and Wnt/b-catenin signalling pathway regulating effects.…”
Section: Introductionmentioning
confidence: 97%
“…The Wnt/β-catenin pathway involved in the early development process of various types of cancer is also involved in the development of CRC (6,7). The key step in activating the Wnt pathway is the stabilization of β-catenin and its translocation into the nucleus, which may serve as a potential target for CRC therapy (8).…”
Section: Introductionmentioning
confidence: 99%