The α6β4 Integrin Is a Receptor for both Laminin and Kalinin

Cytoplasmic expression of laminin γ2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma

“…1,23,24 Recently, it was reported that laminin 5 promotes the migration and invasion of tumor cells in various types of tumors. [5][6][7][8][9][10] In patients with pancreatic carcinoma, Tani et al reported that pancreatic carcinomas synthesize and deposit laminin 5 in the basement membrane, and invading cells supposedly migrate on the newly deposited basement membrane.…”

Sustainable correction of junctional epidermolysis bullosa via transposon-mediated nonviral gene transfer

“…2,[21][22][23] This finding points to a post-transcriptional process, potentially facilitated by physical interactions with other laminin 5 chains and corresponding ligands, such as a6b4 integrin and Type VII collagen, that may direct correct laminin b3 distribution. 13,14 Normalization of JEB skin tissue occurred at the levels of tissue laminin 5 expression and hemidesmosome formation. The presence of hemidesmosomes, the restored expression of laminin 5 and the absence of junctional blistering are strong indicators that tissue cohesion was normalized.…”

“…It interacts physically with a6b4 integrin on the basal surface of epidermal keratinocytes to promote hemidesmosome formation as well as with Type VII collagen in dermal anchoring fibrils to enhance basement membrane zone integrity. 13,14 In facilitating these processes, laminin 5 plays a nonredundant role in epidermal-dermal adhesion. 12,15 Recently, Moloney murine leukemia-based amphotropic retroviruses have been used to transduce successfully LAMB3 mutant stem cells from JEB patient epidermis.…”

The role of the transcriptional regulator snail in cell detachment, reattachment and migration

“…5 Cell adhesion to laminin-332 occurs by binding through α3β1 and α6β4 integrins. 12 Thus, a reduction in integrin α3 and α6, as well as a decrease in laminin-332, could cause detachment of snail-expressing MDCK and A431 cells. In addition to laminin-332, laminin-α5 is also downregulated in snail transfected SCC cells.…”