The α-Tubulin Deacetylase HDAC6 in Aggresome Formation and Autophagy

Richter‐Landsberg, Christiane

doi:10.1016/b978-0-12-801033-4.00018-7

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Aggregate Formation2

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Cited by 2 publications

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“…Aggresomes have been found to contain not only poly-ubiquitinated protein, but also several chaperones, especially HSPs, which are known to be upregulated in cells as a first line of defense against proteotoxic stress [169]. The AAA-ATPase VCP/p97 facilitates the extraction of unfolded proteins from the ER during ERAD, and then further controls the transport of these proteins towards the proteasome [162].…”

Section: Aggregate Formationmentioning

confidence: 99%

“…This unique deacetylase contains a C-terminal zinc-finger motif that allows it to bind to ubiquitin chains with high affinity [171,172]. HDAC6 also contains a dynein-binding domain that allows it to link unfolded protein to dynein motors on the cytoskeleton for transport to the aggresome at the MTOC [169]. Aggresome formation is therefore dependent on cytoskeletal integrity.…”

Section: Aggregate Formationmentioning

confidence: 99%

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