The α’ subunit of β-conglycinin and various glycinin subunits of soy are not required to modulate hepatic lipid metabolism in rats

Chatterjee, Cynthia; Liu, Jiajie; Wood, Carla M.; Gagnon, Christine; Cober, Elroy R.; Frégeau‐Reid, Judith; Gleddie, S.; Xiao, Chao-Wu

doi:10.1007/s00394-017-1399-x

Cited by 9 publications

(3 citation statements)

References 43 publications

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“…The results showed that soybean protein lacking the β-conglycinin α′ subunit and glycinin A1–5 subunit had similar lipid-lowering functions as conventional soybean protein, but the bioactive components in soybean responsible for the lowered lipid were not clear. 1 Research shows that the α + α′ subunit had higher LDL reception and its upregulation activity was higher than that of the β subunit. 9 Previous studies have shown that the effect of soybean 7S globulin subunits on the upregulation of LDL receptors in HepG2 cells confirms the effective roles of these subunits.…”

Section: Resultsmentioning

confidence: 99%

“…In recent years, advancements in food science and processing technologies as well as changes in the health concepts of consumers have led to soy protein isolate (SPI) being widely used as a food processing raw material to increase nutritional value and improve product quality. [1][2][3][4] SPI is mainly composed of two proteins, β-conglycinin (7S) and glycinin (11S). 7S is a trimeric glycoprotein (150-200 kDa), mainly comprising α (72 kDa), α′ (76 kDa) and β (53 kDa) peptides.…”

Section: Introductionmentioning

confidence: 99%

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Potential functionality of β-conglycinin with subunit deficiencies: soy protein may regulate glucose and lipid metabolism

Shan

et al. 2022

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential functionality of β-conglycinin with subunit deficiencies: soy protein may regulate glucose and lipid metabolism

Shan

et al. 2022

Food Funct.

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“…β -conglycinin, one of the major storage proteins in soybean, was shown to reduce serum triglycerides, glucose and insulin levels [ 12 ], and prevented high-fat induced fatty liver in mice [ 59 ], and increased blood adiponectin level and insulin sensitivity in Wistar rats [ 23 ]. Our studies, using soy proteins with depletion of different subunits, further demonstrated that α ’ subunit of β -conglycinin and all acidic polypeptides (A1 to A5) in glycinin were not required for the lipid-lowering effects and fatty liver reduction of soy proteins [ 60 , 61 ]. This indicates that the other subunits of β -conglycinin and glycinin may play major roles in this regard.…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic Effects of Soy Protein and Isoflavones in the Prevention of Non-Alcoholic Fatty Liver Disease- A Review

Xiao

Hendry

2022

Plant Foods Hum Nutr

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and affects about 25% of the population globally. Obesity and diabetes are the main causes of the disease characterized by excessive accumulation of lipids in the liver. There is currently no direct pharmacological treatments for NAFLD. Dietary intervention and lifestyle modification are the key strategies in the prevention and treatment of the disease. Soy consumption is associated with many health benefits such as decreased incidence of coronary heart disease, type-2 diabetes, atherosclerosis and obesity. The hypolipidemic functions of soy components have been shown in both animal studies and human clinical trials. Dietary soy proteins and associated isoflavones suppressed the formation and accumulation of lipid droplets in the liver and improved NAFLD-associated metabolic syndrome. The molecular mechanism(s) underlying the effects of soy components are mainly through modulation of transcription factors, sterol regulatory element-binding protein-1 and peroxisome proliferator-activated receptor-γ2, and expressions of their target genes involved in lipogenesis and lipolysis as well as lipid droplet-promoting protein, fat-specific protein-27. Inclusion of appropriate amounts of soy protein and isoflavones in the diets might be a useful approach to decrease the prevalence of NAFLD and mitigate disease burden.

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Dietary l-lysine supplementation altered the content of pancreatic polypeptide, enzymes involved in glutamine metabolism, and β-actin in rats

2018

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This study investigated the effects of Lys supplementation on serum pancreatic polypeptide (PP), glutamine (Gln) levels and the expression of PP, Gln synthetase (GlnS), glutaminase (Gls) and β-actin in different tissues such as pancreas, skeletal muscle, liver and kidney in rats. Male Sprague-Dawley rats were fed diets containing 7% casein supplemented with either 0% (Control), 1%, 1.5%, 3% Lys or 3% Lys with 1.5% Arg for a week. All rats were necropsied for collection of blood and tissues. Expression of PP, GlnS, Gls, and β-actin in tissues were determined using Western blotting. The results showed that the rats fed 3% supplemental Lys had significantly lower body weight gain (BWG) and food intake than the ≤ 1.5% Lys groups (P < 0.05). Supplementation with ≥ 1% Lys increased serum PP level (P < 0.05), but had no significant effect on pancreatic PP abundance (P > 0.05). GlnS expression was significantly lowered in skeletal muscle by ≥ 1.5% supplemental Lys compared to the Control (P < 0.05). The expression of Gls in the kidney was increased by the addition of 1.5% Arg to 3% Lys diet (P < 0.05). Liver β-actin significantly increased with both Lys and Arg supplementation and muscle β-actin significantly decreased (P < 0.05) with ≥ 1.5% supplemental Lys. Kidney β-actin significantly increased with Arg supplementation vs 3% Lys alone (P < 0.05). These results showed that dietary supplementation with ≥ 1.5% Lys significantly suppressed GlnS expression in the skeletal muscle, which may contribute to the decreased serum Gln levels, and that increased serum PP by Lys may be due to suppressed catabolism rather than increased synthesis of PP. Lys-induced PP may play a role in reducing food intake and BWG.

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The α’ subunit of β-conglycinin and various glycinin subunits of soy are not required to modulate hepatic lipid metabolism in rats

Abstract: Overall, soy protein deficient in the α' subunit of β-conglycinin and A1-5 subunits of glycinin maintain similar hypolipidemic function compared to the conventional soy protein. The exact bioactive component(s) warrant identification.

Cited by 9 publications

References 43 publications

Potential functionality of β-conglycinin with subunit deficiencies: soy protein may regulate glucose and lipid metabolism

Potential functionality of β-conglycinin with subunit deficiencies: soy protein may regulate glucose and lipid metabolism

Hypolipidemic Effects of Soy Protein and Isoflavones in the Prevention of Non-Alcoholic Fatty Liver Disease- A Review

Dietary l-lysine supplementation altered the content of pancreatic polypeptide, enzymes involved in glutamine metabolism, and β-actin in rats

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