The onset of quartetting, i.e. α-particle condensation, in symmetric nuclear matter is studied with the help of an in-medium modified four nucleon equation. It is found that at very low density quartetting wins over pairing, because of the strong binding of the α-particles. The critical temperature can reach values up to around 6 MeV. Also the disappearance of α-particles with increasing density, i.e. the Mott transition, is investigated. In finite nuclei the Hoyle state, that is the 0 2 + of 12 C, is identified as an "α-particle condensate" state. It is conjectured that such states also exist in heavier nα-nuclei, like 16 O, 20 Ne, etc. For instance the 6-th 0 + state of 16 O at 15.1 MeV is identified from a theoretical analysis as being a strong candidate for an α condensate state. Exploratory calculations are performed for the density dependence of the α condensate fraction at zero temperature to address the suppression of the four-particle condensate below nuclear-matter density. Possible quartet condensation in other systems is discussed briefly.