The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis (Adv. Sci. 17/2023)

Abstract

In article number 2205345, Fudi Wang, Junxia Min, and co-workers identify and demonstrate indispensable function of zinc transporter SLC39A10 (ZIP10) and its mediated zinc homeostasis for maintaining the survival of fetal hematopoietic stem/progenitor cells. As the most important zinc importer on the cell membrane of hematopoietic stem cells, ZIP10 functions as a gatekeeper (like a vacuum to transport zinc across a cell membrane) for orchestrating zinc acquisition and the fate of stem cells.