The Zebrafish World of Colors and Shapes: Preference and Discrimination

Oliveira, Jéssica Janine de; Silveira, Mayara M.; Chacon, Diana Marques Martins; Luchiari, Ana Carolina

doi:10.1089/zeb.2014.1019

Cited by 103 publications

(97 citation statements)

References 78 publications

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“…Some authors report a clear blue aversion, 4,9 whereas others report a blue preference. [10][11][12][13] Again the location of the color is of critical importance. Although the Avdesh group 4,9 used colors on the bottom, all other investigators used colors on the walls.…”

Section: Discussionmentioning

confidence: 99%

“…Although the Avdesh group 4,9 used colors on the bottom, all other investigators used colors on the walls. [10][11][12][13] The clearest discriminations are observed when yellow zones are compared with blue zones. Almost all animals immediately swim into the blue zone.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors report a clear aversion for the color blue, 2,4,9 whereas others show a strong preference for this color. [10][11][12][13] It is also not known whether the color preference of zebrafish larvae and adults is identical or develops over time. Color preference can furthermore be induced by a preference for one color or an aversion for the alternative.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Color Preference in Danio rerio: Effects of Age and Anxiolytic Treatments

Peeters¹,

Moeskops²,

Veenvliet³

2016

Zebrafish

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Zebrafish are increasingly used in neurobiological and behavioral studies. Possible stimuli to manipulate zebrafish behavior are being investigated. The presentation of colors appears to be one of the most used approaches, but there is much debate about the exact color preference. Here we have investigated the color preference in both larvae and adult zebrafish. We have studied the effects of wavelength, contrast, intensity, and location. Furthermore, we have tried to manipulate the preference with anxiolytic drugs (ethanol and buspirone). Our results show that both adults and larvae have a clear preference for blue zones while they avoid yellow-colored zones. Red and green zones have an intermediate preference. Part of the yellow aversion is caused by a fear for this color and can be diminished by the treatment with anxiolytic drugs. The location of the color appears to be of critical importance. Presentation of the color on the walls induces an approach response whereas presentation on the bottom induces an aversion. In conclusion, colors are important stimuli to manipulate zebrafish behavior and can be used in behavioral models. Standardization of the procedures and a clear description of the used methodologies are, however, essential.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Color Preference in Danio rerio: Effects of Age and Anxiolytic Treatments

Peeters¹,

Moeskops²,

Veenvliet³

2016

Zebrafish

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“…The novel object (B) were always randomized between the animals. Objects in colors green and blue were not used during this trials due to previous records of zebrafish preference for these colors (Avdesh et al, 2010; Oliveira et al, 2015). On this phase, each fish was transferred to the test tank for 20 min exploring the objects and behavior was recorded from above.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, this study evaluates the effect of Ayahuasca exposure, both acute and chronic, in the performance of zebrafish on a cognitive task. For this, we used a more vulnerable type of memory, based on one-trial recognition test (Oliveira et al, 2015), due to its sensibility to most psychostimulant substances and rapid response for highly impacting psychedelic substances such as Ayahuasca.…”

Section: Introductionmentioning

confidence: 99%

It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish

Lobão-Soares

Eduardo-da-Silva

Amarilha

et al. 2018

Front. Behav. Neurosci.

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Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to potential cognitive benefits. Ayahuasca effects are caused by the synergistic interaction of β-carbolines (harmine, harmaline and tetrahydroarmine) contained in Banisteriopsis caapi stalks combined with the N,N-dimethyltryptamine (DMT) from Psychotria viridis leaves, a potent agonist to serotonin (5-HT) receptors. The present study approaches the effects of chronic and acute exposure to two Ayahuasca concentrations (0.1 and 0.5 ml/L) on the cognitive ability to discriminate objects in a one-trial learning task in zebrafish. Based on the combination of concentrations and exposure regimens, we divided adult zebrafish in five treatment groups: acute 0.1 and 0.5 ml/L, chronic 0.1 and 0.5 ml/L, and control 0.0 (n = 20 for each group). Then we tested them in a memory task of object discrimination. Acute Ayahuasca exposed groups performed similarly to the control group, however chronically treated fish (13 days) presented both impaired discriminative performance and locomotor alterations. Overall, these results indicate that Ayahuasca is a potent psychoactive drug that, in chronic exposure, negatively affects mnemonic parameters in zebrafish. In single exposure it does not affects cognitive performance, but the higher concentration (0.5) affected locomotion. Moreover, we reinforce the importance of the zebrafish for behavioral pharmacological studies of drug screening, in special to psychedelic drug research.

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Directional and color preference in adult zebrafish: Implications in behavioral and learning assays in neurotoxicology studies

Bault

Peterson

Freeman

2015

J of Applied Toxicology

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The zebrafish (Danio rerio) is a useful vertebrate model organism for neurological studies. While a number of behavior and learning assays are recently reported in the literature for zebrafish, many of these assays are still being refined. The initial purpose of this study was to apply a published T-maze assay for adult zebrafish that measures how quickly an organism can discriminate between different color stimuli after receiving reinforcement to measure learning in a study investigating the later life impacts of developmental Pb exposure. The original results were inconclusive as the control group showed a directional and color preference. To assess directional preference further, a three-chambered testing apparatus was constructed and rotated in several directions. The directional preference observed in males was alleviated by rotating the arms pointing west and east. In addition, color preference was investigated using all combinations of five different colors (orange, yellow, green, blue and purple). With directional preference alleviated results showed that both male and female zebrafish preferred colors of shorter wavelengths. An additional experiment tested changes in color preference due to developmental exposure to Pb in adult male zebrafish. Results revealed that Pb-exposed males gained and lost certain color preferences compared to control males and the preference for short wavelengths was decreased. Overall, these results show that consideration and pretesting should be completed before applying behavioral and learning assays involving adult zebrafish to avoid innate preferences and confounding changes in neurotoxicology studies and that developmental Pb exposure alters color preferences in adult male zebrafish.

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The Zebrafish World of Colors and Shapes: Preference and Discrimination

Cited by 103 publications

References 78 publications

Color Preference in Danio rerio: Effects of Age and Anxiolytic Treatments

Color Preference in Danio rerio: Effects of Age and Anxiolytic Treatments

It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish

Directional and color preference in adult zebrafish: Implications in behavioral and learning assays in neurotoxicology studies

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