The zebrafish heart —A suitable model for human cardiology?

Shiels, Holly A.; Cros, Caroline; Dixey, Hayley; Wilson, Claire; Luxán, Guillermo; Brette, Fabien

doi:10.1016/j.cbpa.2009.04.071

Cited by 4 publications

(2 citation statements)

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“…Over the past 20 years, the zebrafish (Danio rerio) has attracted considerable attention as an excellent vertebrate model system for studying genetics and development (Fishman 2001), and more recently, for understanding human disease and for the screening of therapeutic drugs (Penberthy et al 2002, Sumanas & Lin 2004, Keller et al 2006, Shiels et al 2009.…”

Section: Introductionmentioning

confidence: 99%

Increase of fecundity by probiotic administration in zebrafish (Danio rerio)

Gioacchini

Maradonna²,

Lombardo³

et al. 2010

Reproduction

107

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It is well known established that reproduction is sensitive to the state of energy reserves, and that there is a balance between energy homeostasis and fertility. In this view, this study examined the effects of the probiotic Lactobacillus rhamnosus, as a feed additive, on zebrafish (Danio rerio) fecundity. Ten days of probiotic treatment modulate the gene expression of neuropeptide hormones and metabolic signals, such as kiss1, kiss2 and leptin both at the CNS level and at the peripheral level. The increase in fecundity brought about by the probiotic was demonstrated by the higher number of ovulated eggs in vivo and by the higher germinal vesicle breakdown rate obtained with the in vitro maturation assay. The increase in oocyte maturation was associated with increased transcription of genes coding for signals which induce the maturation phase, such as lhcgr, cbr1l, and paqr8 genes, concomitant with a decreased transcription of genes coding for local factors which prevent oocyte maturation, such as tgfb1, gdf9, and bmp15. In conclusion, all these findings highlight the action of L. rhamnosus both on the endocrine system and at the local level by inducing oocyte maturation. The significance of the results herein obtained underlined the importance of diet in the reproductive process, supporting the hypothesis that feed additives can improve fecundity. Considering that the zebrafish has been clearly established as a vertebrate model for biomedical research, these results support the potentiality of feed additives such as probiotics, frequently used in the human diet, as a new technology to improve reproduction in all vertebrates, including humans.

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Section: Introductionmentioning

confidence: 99%

Increase of fecundity by probiotic administration in zebrafish (Danio rerio)

Gioacchini

Maradonna²,

Lombardo³

et al. 2010

Reproduction

107

View full text Add to dashboard Cite

show abstract

“…For this purpose, food intake and changes in the gene expression of the major molecules involved in feeding regulation were studied in the zebrafish Danio rerio. This experimental model, over the past twenty years, has attracted considerable attention as an excellent vertebrate model system for studying genetics and development (Fishman, 2001), and more recently, for human disease understanding and for the screening of therapeutic drug, so that zebrafish is recognized as a powerful pharmacological tool (Penberthy et al, 2002;Goldsmith, 2004;Sumanas and Lin, 2004;Keller et al, 2006;Shiels et al, 2009).…”

Section: Introductionmentioning

confidence: 99%