The Zagreb Collection of human brains: entering the virtual world

Hrabač, Pero; Bosak, Ana; Vukšić, Mario; Judaš, Miloš; Kostović, Ivica; Krsnik, Željka

doi:10.3325/10.3325/cmj.2018.59.283

Cited by 11 publications

(13 citation statements)

References 10 publications

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“…Human developmental tissues were obtained through the joint Medical Research Council (MRC)/Wellcome Trust Human Developmental Biology Resource (HDBR) (Gerrelli et al, 2015), the Zagreb Research Brain Collection (Hrabac et al, 2018) and BRAINUK neuropathology centres (Fig 1; Supplementary table 1 for demographics of cases and acknowledgements for participating BRAINUK centres). Tissues were collected with appropriate maternal consent and approval for use in research.…”

Section: Methodsmentioning

confidence: 99%

“…We would like to thank the joint MRC/Wellcome Trust Human Developmental Biology Resource (HDBR) (grant # MR/006237/1) (Gerrelli et al, 2015; Lindsay et al, 2016), the Zagreb Research Brain Collection (Hrabac et al, 2018), and BRAIN UK, a collaboration between representatives from the University of Southampton, Plymouth Hospitals NHS Trust, the University of Bristol, and a network of many NHS neuropathology centres across the United Kingdom. BRAINUK is funded by the MRC and Brain Tumour Research.…”

Section: Acknowledgementsmentioning

confidence: 99%

“…Human developmental tissues were obtained through the joint Medical Research Council (MRC)/Wellcome Trust Human Developmental Biology Resource (HDBR) (Gerrelli et al, 2015), the Zagreb Research Brain Collection (Hrabac et al, 2018) et al, 2004). We used here postconceptional age consistent with HDBR guidelines which is estimated at 2 weeks earlier than gestational age (Supplementary table 1).…”

Section: Human Tissuesmentioning

confidence: 99%

“…Zagreb Research Brain Collection (Hrabac et al, 2018) (Bian et al, 2020;Cao et al, 2020;Fan et al, 2020;Kracht et al, 2020) between 3-24 postconceptional weeks.…”

Section: )mentioning

confidence: 99%

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Spatiotemporal dynamics of human microglia are linked with brain developmental processes across the lifespan

Menassa

Muntslag

Margarida

et al. 2021

Preprint

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SUMMARYMicroglia, the brain’s resident macrophages, shape neural development and wiring, and are key neuroimmune hubs in the pathological signature of neurodevelopmental disorders. In the human brain, microglial development has not been carefully examined yet, and most of our knowledge derives from rodents. We established an unprecedented collection of 97 postmortem tissues enabling quantitative, sex-matched, detailed analysis of microglial across the human lifespan. We identify the dynamics of these cells in the human telencephalon, describing novel waves in microglial density across gestation and infancy, controlled by a balance of proliferation and apoptosis, which track key neurodevelopmental milestones. These profound changes in microglia are also observed in bulk RNAseq and single-cell RNAseq datasets. This study provides unparalleled insight and detail into the spatiotemporal dynamics of microglia across the human lifespan. Our findings serve as a solid foundation for elucidating how microglia contribute to shaping neurodevelopment in humans.

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Section: Methodsmentioning

confidence: 99%

Section: Acknowledgementsmentioning

confidence: 99%

“…Human developmental tissues were obtained through the joint Medical Research Council (MRC)/Wellcome Trust Human Developmental Biology Resource (HDBR) (Gerrelli et al, 2015), the Zagreb Research Brain Collection (Hrabac et al, 2018) et al, 2004). We used here postconceptional age consistent with HDBR guidelines which is estimated at 2 weeks earlier than gestational age (Supplementary table 1).…”

Section: Human Tissuesmentioning

confidence: 99%

“…Zagreb Research Brain Collection (Hrabac et al, 2018) (Bian et al, 2020;Cao et al, 2020;Fan et al, 2020;Kracht et al, 2020) between 3-24 postconceptional weeks.…”

Section: )mentioning

confidence: 99%

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Spatiotemporal dynamics of human microglia are linked with brain developmental processes across the lifespan

Menassa

Muntslag

Margarida

et al. 2021

Preprint

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“…Their project is ongoing. 18 Advanced software programs are necessary to appropriately store and categorize digitized images in order to enable easy browsing capability. 19 Such technology is critically important today, as is evidenced by the large photo databases available, including Dermnet and VisualDX.…”

Section: Introductionmentioning

confidence: 99%

Buried treasure – the teaching potential of Kodachrome slides brought into the digital age

et al. 2021

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Clinical images on Kodachrome slides have been used for decades in dermatologic education. While the technology to view these images is becoming obsolete, many training programs possess high-quality slides that have educational benefit. The University of Virginia Department of Dermatology possesses a collection of such slides that are currently being digitized and integrated into an educational software program. We present this article as a means of providing a uniform protocol for institutions with large Kodachrome collections to do the same. Our work has proven beneficial for both medical students interested in dermatology, allowing them to gain exposure to a variety of conditions that are not well emphasized in the general curriculum, as well as for dermatology residents, who use the program as a means to hone their diagnostic skills. Not only is there educational benefit to be derived from digitizing these slides but time is of the essence, as these slides can easily become damaged or degraded, and the technology needed to scan them is quickly becoming less available.

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Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits

Petanjek,

Banovac,

Sedmak

et al. 2023

Advances in Neurobiology

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The Zagreb Collection of human brains: entering the virtual world

Cited by 11 publications

References 10 publications

Spatiotemporal dynamics of human microglia are linked with brain developmental processes across the lifespan

Spatiotemporal dynamics of human microglia are linked with brain developmental processes across the lifespan

Buried treasure – the teaching potential of Kodachrome slides brought into the digital age

Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits

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