In this article, we introduce a new kind of split monotone variational inclusion problem involving Cayley operator in the setting of infinite-dimensional Hilbert spaces. We develop a general iterative method to approximate the solution of the split monotone variational inclusion problem involving Cayley operator. Under some suitable conditions, a convergence theorem for the sequences generated by the proposed iterative scheme is established, which also solves certain variational inequality problems related to strongly positive linear operators. Finally, a numerical example is presented to study the efficiency of the proposed algorithm through MATLAB programming.