The yelandur study: a community-based approach to epilepsy in rural south India—epidemiological aspects

Mani, K.; Rangan, G.; Srinivas, HV; Kalyanasundaram, S.; Narendran, Siddharth; Reddy, Ananda

doi:10.1016/s1059-1311(98)80019-8

Cited by 93 publications

(90 citation statements)

References 11 publications

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“…Thus, the most important risk factors acting in developing countries may have influenced this age group in the past and perhaps still have an influence with diseases such as neurocysticercosis, infectious diseases and sanitary health problems [34][35][36][37] .…”

Section: Discussionmentioning

confidence: 99%

Urban prevalence of epilepsy: populational study in São José do Rio Preto, a medium-sized city in Brazil

Borges

Guerreiro

et al. 2004

Arq. Neuro-Psiquiatr.

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-The aim of this study was to determine the prevalence of epilepsy in the urban population of São José do Rio Preto. This is a medium-sized city of 336000 inhabitants, located in the northwest of the state of São Paulo, Brazil. Method:A cross-sectional epidemiological investigation with a randomized sample was performed in two phases, a screening phase and a confirmation of the diagnosis phase. The gold standard was a clinical investigation and neurological examination. The chi-square test was used in analysis of the results and p-value value < 0.05 was considered significant. Prevalence was calculated with 95% confidence interval. Results: The study sample size was 17293 individuals, with distributions of gender, age, and race similar to the general population.The prevalence per 1000 inhabitants of epilepsy was 18.6, of these 8.2 were active, defined as at least one seizure within the last two years. The prevalence per 1000 inhabitants for the age groups (years) was 4.9 (0-4), 11.7 (5-14), 20.3 (15-64) and 32.8 (65 or over). Conclusion: Prevalence of both accumulated and active epilepsy was elevated, comparable to other developing nations, in particular those of Latin America. However, the prevalence of epilepsy in childhood was low, whilst in aged individuals it was high similar to industrialized nations.KEY WORDS: epilepsy, epidemiology, prevalence, Latin America. Prevalência urbana da epilepsia: estudo populacional em São José do Rio Preto -cidade de médio porte do BrasilRESUMO -Antecedentes: O objetivo deste estudo foi determinar a prevalência da epilepsia na população urbana de São José do Rio Preto, com 336000 habitantes, localizada no noroeste do Estado de São Paulo/ Brasil. Método: O estudo populacional, tipo corte transversal, em amostra aleatória, constituiu-se de uma fase de rastreamento, mediante um questionário. O padrão ouro para confirmação diagnóstica foi a história clínica e o exame neurológico. Os testes do χ 2 e intervalo de confiança de 95% (IC-95%) foram usados para análise dos resultados, tendo sido considerados significantes os de valor p≤ 0,05. Resultados:A amostra estudada foi de 17293 pessoas, cuja distribuição quanto ao sexo, à faixa etária e à raça foram semelhantes à da população em geral. A prevalência de epilepsia por 1000 hab. foi 18,6, sendo 8,2 para ativa considerando-se, pelo menos, uma crise no período dos últi-mos 2 anos. A prevalência na faixa etária de 0 a 4 anos foi 4,9, de 5 a 14, 11,7; de 15 a 64, 20,3; e acima dos 65 anos foi 32,8. Conclusão: As prevalências de epilepsia acumulada e ativa foram elevadas, semelhantes às dos países em desenvolvimento, em particular, aos da América Latina. A prevalência de epilepsia na infância foi baixa, enquanto que nos idosos foi elevada, semelhantes às observadas em países desenvolvidos. Estes resultados são relevantes no planejamento de medidas sanitárias, adequação ao tratamento da população, considerando a alta prevalência encontrada, para minimizar o impacto da epilepsia na população.

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Section: Discussionmentioning

confidence: 99%

Urban prevalence of epilepsy: populational study in São José do Rio Preto, a medium-sized city in Brazil

Borges

Guerreiro

et al. 2004

Arq. Neuro-Psiquiatr.

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“…Hauser (19) estimated, based on 32 studies in different parts of the world, an average prevalence rate of 5.2 per 1,000 population. Three recent community-based epilepsy surveys representing north, central, and south India, have shown prevalence rates per 1,000 population of 2.5 for Kashmir (20), 3.6 for the Parsis in Bombay (21), and 4.4 for Bangalore (22). Sridharan and Murthy (23) recently undertook a meta-analysis of the prevalence data obtained from 20 community-based studies on epilepsy in India.…”

Section: The Prevalence Studymentioning

confidence: 99%

Prevalence, Knowledge, Attitude, and Practice of Epilepsy in Kerala, South India

et al. 2000

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Summary:Purpose: To ascertain the prevalence and pattern of epilepsy and to characterize and quantify knowledge, attitude, and practice (KAP) toward epilepsy among the people of the state of Kerala, which is distinguished from the rest of India by a high level of literacy and health awareness of its population.Methods: We conducted a door-to-door survey covering the entire population of 238, I02 people residing in 43,68 I households in a seniiurban area of central Kerala. The screening questionnaire administered by medical social workers had a sensitivity of 100% for identifying persons with epilepsy. Neurologists examined all the individuals suspected of having epilepsy. We evaluated KAP toward epilepsy among 1,118 subjects (439 males and 679 females; mean age, 33.3 years; age range, 15-85 years) from households without epilepsy in the study area.Results: Through a three-phased survey, we ascertained 1,175 cases (6 16 males and 559 females) with active epilepsy, providing a crude point prevalence ratio of 4.9 cases per 1,000 people and an age-adjusted prevalence ratio of 4.7 cases per 1,000 population. The highest age-specific prevalence rate of 6.5 per 1,000 occurred in the 10-to 19-year-old age group. Sex-specific prevalence rates did not significantly differ. The proportion of generalized and localization-related epilepsies was 58.8% and 30.6%, respectively. Ninety-nine percent of the KAP respondents had read or heard about epilepsy. Thirty-one percent and 27% thought epilepsy was a hereditary disorder and a form of insanity, respectively. About 40% of the respondents felt that individuals with epilepsy could not be properly educated or employed. Eleven percent would object to their children having contact with epileptic children.Conclusions: The prevalence and pattern of epilepsy in central Kerala, South India, do not differ from that of developed countries. Although the awareness of epilepsy among the people of Kerala was comparable to that of developed countries, the attitudes were much more negative. The need for educating the people of Kerala on epilepsy and for incorporating an adequate knowledge of epilepsy in the school curricula cannot be overemphasized. Key Words: Epidemiology-Epilepsy-Knowledge, attitude and practice-KAP-Prevalence.Population-based studies, in contrast to hospital-based studies, provide a relatively unbiased picture of various aspects of the disease in question. Prevalence is a measure of the disease burden in the community, which has to be considered when planning the health needs at local, regional, and national levels. Knowing the degree of awareness and attitude toward a disease in a society is a necessary first step in eliminating discrimination against persons with that disease.

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“…7 while it was 3.28-5.7/1,000 in South India. 8 Recurrence of febrile seizure ranges from 21-43% in different studies. 9,10,11 Risk factors of recurrence after a first febrile seizure based on various studies are:…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Recurrence of Febrile Seizures in Children Aged Between 6 Months to 5 Years of Age Admitted to Dr. Punjabrao Deshmukh Medical College, Amravati

Rane¹,

Nistane²,

Barabde³

et al. 2015

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Febrile seizures (FS) occur in 2% to 5% of all children and are most common convulsive event in children younger than 60 month. Recurrence of FS ranges from 21-43% in different studies and are associated with various risk factors like age of onset of 1 st episode of FS less than 1 year, duration and grade of fever, parental consanguinity, family history of FS and epilepsy, male gender and complex FS as initial seizure. AIMS AND OBJECTIVE: The purpose of this study was to evaluate the risk factors and their association for recurrences of febrile seizures in children aged between 6 months to 5 years of age. MATERIALS & METHODS:The study design was prospective observational study in which 63 children (6 months to 5 years) presenting with the first episode of FS to Dr. Punjabrao Deshmukh Medical College, Amravati between 1 st November 2013 to 31 st October 2014 were enrolled in the study. These subjects were followed up for a period of 1 year from the date of 1 st episode of FS. RESULTS: In present study 46 out of 63 subjects had recurrence of FS. Male: female ratio in the recurrence group was 0.76:1. Family history of FS and epilepsy was present in 34.9% and 12.6% respectively. Total 67.34% subjects with simple FS and 92.85% with complex FS had recurrence. 69.69% subjects had FS within 24 hours of onset of fever. Parental consanguinity was found in 14 (22.2%) subjects with p value of 0.013. No association between the number of risk factors and recurrence was found. 22 (34.9%) out of total 63 subjects were on intermittent FS prophylaxis during the febrile illness and 15 subjects still had recurrence of FS and hence no significant association between recurrence of FS and intermittent prophylaxis for FS was seen. CONCLUSION: Parental consanguinity and age less than one year for 1 st episode of FS were the only significant risk factors indentified for the recurrence of FS. Age of onset of 1 st episode of FS less than 1 year, duration of fever, grade of fever, family history of FS and epilepsy, male gender and complex febrile seizure as initial seizure were not found to be significantly associated with recurrence of FS. No significant association between the numbers of risk factors and recurrence of FS was found. Prescribing prophylaxis for FS statistically did not show any benefit in decreasing the frequency nor completely stop the recurrences of FS.

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The yelandur study: a community-based approach to epilepsy in rural south India—epidemiological aspects

Cited by 93 publications

References 11 publications

Urban prevalence of epilepsy: populational study in São José do Rio Preto, a medium-sized city in Brazil

Urban prevalence of epilepsy: populational study in São José do Rio Preto, a medium-sized city in Brazil

Prevalence, Knowledge, Attitude, and Practice of Epilepsy in Kerala, South India

Risk Factors for Recurrence of Febrile Seizures in Children Aged Between 6 Months to 5 Years of Age Admitted to Dr. Punjabrao Deshmukh Medical College, Amravati

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