Abstract:Background: The POLG gene encodes the catalytic subunit of DNA polymerase γ, which is crucial for mitochondrial DNA (mtDNA) repair and replication. Gene mutation alters the stability of mtDNA and is associated with several clinical presentations, such as dysarthria and ophthalmoplegia (SANDO), progressive external ophthalmoplegia (PEO), spinocerebellar ataxia and epilepsy (SCAE), Alpers syndrome, and sensory ataxic neuropathy. Recent evidence has also indicated that POLG mutations may be involved in some neuro… Show more
“…The presence of clinical similarities between different forms of dementia and other neurodegenerative disorders raises the question as to whether common molecular pathways might explain shared clinical symptoms. Although several mechanisms have been hypothesized, at both the cellular and neuronal network levels [1,2], the exact molecular mechanisms that lead to dementia and other neurodegenerative disorders are not well-understood.…”
The various forms of dementia and the other neurodegenerative disorders that affect memory, cognition, and behavior have become a public health priority across the developed world [...]
“…The presence of clinical similarities between different forms of dementia and other neurodegenerative disorders raises the question as to whether common molecular pathways might explain shared clinical symptoms. Although several mechanisms have been hypothesized, at both the cellular and neuronal network levels [1,2], the exact molecular mechanisms that lead to dementia and other neurodegenerative disorders are not well-understood.…”
The various forms of dementia and the other neurodegenerative disorders that affect memory, cognition, and behavior have become a public health priority across the developed world [...]
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