Several recent studies have reported different intrinsic correlations between the active galactic nucleus (AGN) mid-IR luminosity (L MIR ) and the rest-frame 2-10 keV luminosity (L X ) for luminous quasars. To understand the origin of the difference in the observed L L X MIR -relations, we study a sample of 3247 spectroscopically confirmed type 1 AGNs collected from Boötes, XMM-COSMOS, XMM-XXL-North, and the Sloan Digital Sky Survey quasars in the Swift/XRT footprint spanning over four orders of magnitude in luminosity. We carefully examine how different observational constraints impact the observed L L X MIR -relations, including the inclusion of X-ray-nondetected objects, possible X-ray absorption in type 1 AGNs, X-ray flux limits, and star formation contamination. We find that the primary factor driving the different L L X MIR -relations reported in the literature is the X-ray flux limits for different studies. When taking these effects into account, we find that the X-ray luminosity and mid-IR luminosity (measured at rest-frame 6 m m , or L 6 m m ) of our sample of type 1 AGNs follow a bilinear relation in the log-log plane: L L log 0.84 0.03 log 10 relation to infer the neutral gas column density for X-ray absorption might overestimate the column densities in luminous quasars.