The X-ray structures, vibrational spectroscopy and antimicrobial activity of nickel(II) complexes with 4-hydroxybenzhydrazide

Zasłona, Halina; Drożdżewski, Piotr; Ślepokura, Katarzyna

doi:10.1016/j.molstruc.2015.06.067

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…HAI are those acquired inside the hospital and in several categories of patients with major contact with the healthcare system, 5 becoming a major health threat worldwide, causing both morbidity and mortality as well as prolonging hospital stay time. 6,7 In view of this problematic situation, coordination chemistry has become increasingly important for the development of new antimicrobial compounds 8,9 and coordination compounds have shown promising antifungal and antibacterial activity against different species. 10,11 In addition, metal complexes can also be used as a solution for the problem of multidrug resistant (MDR) bacteria.…”

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confidence: 99%

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEW Cu (II), Co (II) AND Sn (II) COMPLEXES WITH THE SODIUM HYDROTRIS(2-MERCAPTOTHIAZOLYL)BORATE LIGAND

Ferreira¹,

Andrade²,

Lima³

et al. 2020

Quim. Nova

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Recebido em 27/11/2019; aceito em 05/02/2020; publicado na web em 16/04/2020 The emergence of antibiotic resistance among microbial pathogens is a serious public health problem, resulting in a constant need of discovering new antibiotics. For this purpose, we synthetized and determined the antimicrobial activity of copper (Cu), cobalt (Co), and tin (Sn) complexes coordinated with scorpionate ligand in a tridentate mode against microorganisms of clinical importance. New complexes with the sodium hydrotris(2-mercaptothiazolyl)borate ligand were characterized by physicochemical and spectroscopic techniques (UV-vis, IR, 1 H and 13 C NMR). Moreover, their antimicrobial activity was evaluated using microdilution broth method. Cytotoxicity was determined in Vero cells and the selectivity index (SI) was calculated. The coordination with metals increased the ligand antimicrobial activity, which showed no activity when evaluated alone (MIC>1,080 µM). Cu-complex (1) had activity against Candida albicans and C. krusei, with MICs of 130 and 66 µM, respectively. The compounds had low toxicity on Vero cells and chemo-informatics assays corroborated a low systemic toxic effect. The SI revealed that the compound 1 was 16 times more selective for C. krusei and 8 times more selective for C. albicans in relation to Vero cells. The Cu-complex stands out as a potential prototype for the development of new antifungal agents.

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