The X‐ray Single Crystal Structures of an Acid‐functionalized Bis(2‐picolyl)amine (bpa) Ligand with Palladium(II) and Zinc(II) Display Different Intermoleclar Interactions around the Common (H₂O)₂(anion)₂ Motif

Abstract

This work reports structural investigations on two metal complexes of the functionalized (p‐carboxylatobenzyl)‐bis(2‐picolyl)amine ligand 1 (HL). The complex {[HLPdCl]Cl × H2O}2 (2Pd) has a square‐planar coordination around the Pd ion. It forms discrete dimers by intermolecular hydrogen bonding involving the protonated ligand HL. The coordination around the Zn2+ ion in {[(H2O)LZn]CF3SO3 × 2 H2O}∞ (3Zn) is best described as distorted trigonal‐bipyramidal. The N3O2 ligand sphere is composed of three nitrogen atoms from the bpa ligand, one water molecule, and a carboxylate oxygen atom from a neighbouring molecule, thus forming infinite chains along the crystallographic a axis. Further intermolecular interactions are based on the same (H2O)2(anion)2 motif as for 2Pd, but whereas the former forms discrete dimers, 3Zn forms a more complicated two‐dimensional coordination polymer with additional intermolecular hydrogen bonds.

Cellular Uptake Quantification of Metalated Peptide and Peptide Nucleic Acid Bioconjugates by Atomic Absorption Spectroscopy

“…[20,21] Moreover, carboxylato-functionalized bpa ligands 2 (ester) and 3 (free acid) are readily available (Scheme 1). [5,22] The synthesis of the conjugates studied is shown in Scheme 1. The oligomers bpa-NLS 4, bpa-PNA 5, and bpa-PNA-NLS 6 were prepared by standard 9-fluorenylmethoxycarbonyl (Fmoc) solid-phase peptide synthesis (SPPS) using the bpa acid 3.…”

Quantifizierung der Zellaufnahme metallierter Peptide und Peptidnucleinsäuren durch Atomabsorptionsspektroskopie

“…[20,21] Darüber hinaus sind Carboxylat-funktionalisierte bpa-Liganden wie 2 (Ester) und 3 (freie Säure) sehr gut zugänglich. [5,22] . Die Synthese der in dieser Arbeit untersuchten Biokonjugate ist in Schema 1 gezeigt.…”