The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort

Song, Yuanchao; Hou, Jian; Huang, Xiji; Zhang, Xiaomin; Tan, Aijun; Rong, Yi; Sun, Huizhen; Zhou, Yun; Cui, Xiuqing; Yang, Yuqing; Guo, Yanjun; Zhang, Zhihong; Luo, Xin; Zhang, Bing; Hou, Fan Fan; He, Xiaosheng; Xie, Jungang; Wu, Tangchun; Chen, Weihong; Yuan, Jing

doi:10.1186/1471-2458-14-994

Cited by 103 publications

(30 citation statements)

References 49 publications

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“…In this study, a total of 2645 Wuhan individuals were obtained from the baseline survey (n = 3053) of the Wuhan‐Zhuhai Cohort Study, after exclusion of individuals with missing data on lung function parameters (n = 61), body mass index (BMI) (n = 36), urinary OH‐PAH levels (n = 246), FeNO (n = 121), blood biochemical indices (n = 10), family history of diabetes (n = 16), and waist circumstance (n = 52) …”

Section: Methodsmentioning

confidence: 99%

Environmental exposure to polycyclic aromatic hydrocarbons, kitchen ventilation, fractional exhaled nitric oxide, and risk of diabetes among Chinese females

et al. 2018

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Diabetes is related to exposure to polycyclic aromatic hydrocarbons (PAHs), inflammation in the body, and housing characters. However, associations of urinary monohydroxy-PAHs (OH-PAHs) or fractional exhaled nitric oxide (FeNO) with diabetes risk in relation to housing characters are unclear. In this study, 2645 individuals were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. Associations of diabetes with urinary OH-PAHs or FeNO among cooking participants were estimated using logistic regression models. Among women with self-cooking meals, urinary OH-PAH levels were positively associated with diabetes risk (P < .05); the cooking women with high FeNO (≥25 ppb) had a 59% increase in the risk of diabetes (OR: 1.59, 95% CI: 1.06, 2.38), compared with those with low FeNO (<25 ppb). The cooking women with use of kitchen exhaust fans/hoods had a 52% decrease in the risk of diabetes (OR: 0.48, 95% CI: 0.27, 0.84), compared with those with nonuse of kitchen exhaust fans/hoods. The results indicated that the cooking women had an elevated risk of diabetes, which may be partly explained by an increase in the PAH body burden and higher inflammatory responses. Use of kitchen exhaust fan/hood can be associated with a lower risk of diabetes.

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Section: Methodsmentioning

confidence: 99%

Environmental exposure to polycyclic aromatic hydrocarbons, kitchen ventilation, fractional exhaled nitric oxide, and risk of diabetes among Chinese females

et al. 2018

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“…A pilot study of 109 subjects with the availability of personal 24-h exposure to ambient PM 2.5 and PM 10 and blood were recruited from a community-based, prospective cohort study conducted between April and May of 2011 in Wuhan City, China [ 37 ]. These subjects resided in two distinct communities of Wuhan City; one is located in the urban district and the other is in the suburb.…”

Section: Methodsmentioning

confidence: 99%

“…These subjects resided in two distinct communities of Wuhan City; one is located in the urban district and the other is in the suburb. All subjects have been living in the sampling buildings for >5 years and aged >40 years, free of chronic diseases based on physical examination [ 37 ]. Each individual was interviewed by using a structure questionnaire including tobacco smoking, alcohol use, and environment exposure history.…”

Section: Methodsmentioning

confidence: 99%

Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells

et al. 2015

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Long-term exposure to airborne PM2.5 is associated with increased lung cancer risk but the underlying mechanism remains unclear. We characterized global microRNA and mRNA expression in human bronchial epithelial cells exposed to PM2.5 organic extract and integrally analyzed microRNA-mRNA interactions. Foci formation and xenograft tumorigenesis in mice with NIH3T3 cells expressing genes targeted by microRNAs were performed to explore the oncogenic potential of these genes. We also detected plasma levels of candidate microRNAs in subjects exposed to different levels of air PM2.5 and examined the aberrant expression of genes targeted by these microRNAs in human lung cancer. Under our experimental conditions, treatment of cells with PM2.5 extract resulted in downregulation of 138 microRNAs and aberrant expression of 13 mRNAs (11 upregulation and 2 downregulation). In silico and biochemical analyses suggested SLC30A1, SERPINB2 and AKR1C1, among the upregulated genes, as target for miR-182 and miR-185, respectively. Ectopic expression of each of these genes significantly enhanced foci formation in NIH3T3 cells. Following subcutaneous injection of these cells into nude mice, fibrosarcoma were formed from SLC30A1- or SERPINB2-expressing cells. Reduced plasma levels of miR-182 were detected in subjects exposed to high level of PM2.5 than in those exposed to low level of PM2.5 (P = 0.043). Similar results were seen for miR-185 although the difference was not statistically significant (P = 0.328). Increased expressions of SLC30A1, SERPINB2 and AKR1C1 were detected in human lung cancer. These results suggest that modulation of miR-182 and miR-185 and their target genes may contribute to lung carcinogenesis attributable to PM2.5 exposure.

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“…I.e. new technologies including the use of nanoparticles [ 6 , 7 ] or particles in general [ 8 , 9 ] and infectious diseases [ 10 , 11 ] in many working surroundings or musculoskeletal issues [ 12 , 13 ] enforces federal and state authorities to increase the intellectual capacities in this area of the German occupational health system. Also, psychological and lifestyle issues become more and more important in the field [ 14 – 21 ].…”

Section: Discussionmentioning

confidence: 99%

Imbalances in the German public health system - numbers of state-certified occupational physicians and relation to socioeconomic data

Gyo

Boll

Brüggmann

et al. 2016

J Occup Med Toxicol

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BackgroundState-certified occupational physicians who work as civil servants in the Federal Republic of Germany are key players in the German Public Health system. They control i.e. the legal compliance in occupational health and participate in the occupational disease procedures. Despite the role model function of the German Public health system for many developing countries, this area of Public health is debated to have been hampered in the past years by a disregard concerning structural developments.MethodsDifferent databases were screened for occupational health benchmarks. Obtained data were compared to socioeconomic data and indices were calculated.ResultsThe overall numbers of State-certified occupational physicians decreased in Germany between 1992 and 2012 from 136 to 86 (63 %). On the single state level, the ratios of State-certified occupational physicians per 1 Mio. working population ranged from 8 for the state of Saarland to 0.8 for the state of North Rhine Westphalia. A general difference was found for old versus new German states. Also, large differences were present for the ratios of State-certified occupational physicians per 106 employees towards public debt per capita (€) and the ratios of State-certified occupational physicians per Gross Domestic Product (GDP) in the 16 German states in 2012.ConclusionsIn striking contrast to the WHO document on the Occupational safety and health (OSH) system that states in its executive summary that the human and institutional capacities of the German occupational health system are very strong in both quantity and quality, we here show extreme imbalances present at the single state levels that developed over the past 20 years. With a regard to the increasing complexity of the economic system a reversal of this trend should be demanded.

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The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort

Cited by 103 publications

References 49 publications

Environmental exposure to polycyclic aromatic hydrocarbons, kitchen ventilation, fractional exhaled nitric oxide, and risk of diabetes among Chinese females

Environmental exposure to polycyclic aromatic hydrocarbons, kitchen ventilation, fractional exhaled nitric oxide, and risk of diabetes among Chinese females

Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells

Imbalances in the German public health system - numbers of state-certified occupational physicians and relation to socioeconomic data

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