The wound healing effect of botanicals and pure natural substances used in in vivo models

Abstract

Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the speed of wound contraction, the proliferation of epithelial cells, and collagen formation. The need for proper management of acute wounds to be cured and not turned into chronic wounds is a significant clinical challenge. The traditional practice of medicinal plants in many regions of the world has been used in wound healing since ancient times. Recent scientific research introduced evidence of the efficacy of medicinal plants, their phyto-components, and the mechanisms underlying their wound-repairing activity. This review aims to briefly highlight the wound-curing effect of different plant extracts and purely natural substances in excision, incision, and burn experimental animal models with or without infection of mice, rats (diabetic and nondiabetic), and rabbits in the last 5 years. The in vivo studies represented reliable evidence of how powerful natural products are in healing wounds properly. They have good scavenging activity against Reactive oxygen species (ROS) and anti-inflammatory and antimicrobial effects that help in the process of wound healing. It is evident that incorporating bioactive natural products into wound dressings of bio- or synthetic polymers in nanofiber, hydrogel, film, scaffold, and sponge forms showed promising results in different phases of the wound-curing process of haemostasis, inflammation, growth, re-epithelialization, and remodelling.

Antioxidant Efficacy of Green-Synthesized Silver Nanoparticles Promotes Wound Healing in Mice

“…Plant extracts are known to inhibit oxidative stress and inflammatory response. A recent review emphasized that free radical scavenging, anti-inflammatory, and antimicrobial properties of natural products contribute for their wound-healing efficacy in various animal models [ 51 ]. Owing to its antimicrobial and antiseptic property, silver nitrate has been widely used as a cauterizing agent.…”

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

“…These drug-loaded nanofibers facilitate hemostasis, 114 reduce chronic inflammation, 115 enhance cellular activities, 116 inhibit scar formation, 117 promote neovascularization, 116 combat bacterial infections, and promote wound healing. 118,119 3.5.1. Promotion of Hemostasis.…”

“…By incorporation of biologically active substances, such as GFs, cytokines, anti-inflammatory agents, and antibacterial drugs into nanofiber scaffolds, they fulfill various wound healing functions. These drug-loaded nanofibers facilitate hemostasis, reduce chronic inflammation, enhance cellular activities, inhibit scar formation, promote neovascularization, combat bacterial infections, and promote wound healing. , …”

Robotic Arm Trajectory Based on Machine Learning for tracking the wound

“…Haemostasis, commences immediately after an injury and entails the formation of a blood clot to halt bleeding. The primary objective during human skin wound healing is the swift restoration of barrier function (Wang et al, 2016).Stages for wound healing start with phase 1 Hemostasis, phase 2 in ammatory, phase 3 Proleferative and nally phase 4, remodeling with scar formation (Negm, 2023).…”

“…In order to speed up wound contraction, epithelial cell proliferation, and collagen production, the multiple steps of wound repair require the spatial and temporal synchronization of various cell types. An important therapeutic concern is the adequate management of acute wounds to heal and prevent the development of chronic wounds (Negm, 2023).The rst crucial stage of the wound healing process, known as hemostasis, consists of vasoconstriction, platelet aggregation, and thrombus formation (Negm, 2023). Hemostasis is crucial since that is when blood clotting happens to prevent excessive blood loss.This reduces mortality and even strokes during the initial stages of bleeding.According to Lo et al (2020), the gross healthcare expenses for all inpatient wound episodes within our healthcare cluster 2017 were $216 million for hospital care and $596 000 for primary care.Across all wound classi cations, the anticipated gross healthcare cost per patient ranges from USD 15789 to USD 17761.…”