The World Heart Federation's vision for worldwide cardiovascular disease prevention

Yusuf, Salim; Wood, David; Ralston, Johanna; Reddy, K. Srinath

doi:10.1016/s0140-6736(15)60265-3

Cited by 136 publications

(106 citation statements)

References 22 publications

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“…There is a growing intersection of persons with HIV and NCDs in low-and middle-income countries and as such there is a need for further study to evaluate the types of integrated services that are most effective in these countries (Yusuf et al, 2015). Thirteen of 19 studies were from sub-Saharan Africa, only one case report was from Asia and there were no studies from Latin America, highlighting the need for further research in these regions.…”

Section: Implications For Researchmentioning

confidence: 99%

“…The burden of CVD is greatest in low and middle-income countries, where treatment is largely unaffordable or unavailable (Rasha, McKee, Shannon, Chow, & Rangarajan, 2016;WHO, 2013;Yusuf, Wood, Ralston, & Reddy, 2015). It is estimated that over 700 million adults worldwide will be diagnosed with diabetes by 2025; increasingly and disproportionately in low and middle income countries, which lack affordable and available insulin and other essential medicines (NCD-RisC, 2016;WHO, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Integrating cardiovascular diseases, hypertension, and diabetes with HIV services: a systematic review

et al. 2017

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Non-communicable diseases (NCDs), including cardiovascular diseases (CVD), hypertension and diabetes together with HIV infection are among the major public health concerns worldwide. Health services for HIV and NCDs require health systems that provide for people's chronic care needs, which present an opportunity to coordinate efforts and create synergies between programmes to benefit people living with HIV and/or AIDS and NCDs. This review included studies that reported service integration for HIV and/or AIDS with coronary heart diseases, chronic CVD, cerebrovascular diseases (stroke), hypertension or diabetes. We searched multiple databases from inception until October 2015. Articles were screened independently by two reviewers and assessed for risk of bias. 11,057 records were identified with 7,616 after duplicate removal. After screening titles and abstracts, 14 papers addressing 17 distinct interventions met the inclusion criteria. We categorized integration models by diseases (HIV with diabetes, HIV with hypertension and diabetes, HIV with CVD and finally HIV with hypertension and CVD and diabetes). Models also looked at integration from micro (patient focused integration) to macro (system level integrations). Most reported integration of hypertension and diabetes with HIV and AIDS services and described multidisciplinary collaboration, shared protocols, and incorporating screening activities into community campaigns. Integration took place exclusively at the meso-level, with no micro-or macro-level integrations described. Most were descriptive studies, with one cohort study reporting evaluative outcomes. Several innovative initiatives were identified and studies showed that CVD and HIV service integration is feasible.Integration should build on existing protocols and use the community as a locus for advocacy and health services, while promoting multidisciplinary teams, including greater involvement of pharmacists. There is a need for robust and well-designed studies at all levels -particularly macrolevel studies, research looking at long-term outcomes of integration, and research in a more diverse range of countries.

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Section: Implications For Researchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrating cardiovascular diseases, hypertension, and diabetes with HIV services: a systematic review

et al. 2017

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confidence: 99%

Metabolic and Hemostatic Parameters in Pre-Diabetes and Newly Diagnosed Type 2 Diabetes

Петрик¹,

Космачева²,

Bratchik³

et al. 2016

Russ J Cardiol

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Type 2 diabetes mellitus (T2DM) is a significant risk factor for cardiovascular disease [1]. Debuting as a metabolic disease T2DM is accompanied by morphologic changes of the vascular wall, target-organ damaging, developing cardiovascular catastrophes. Atherothrombosis is the leading cause of death in T2DM. People with DM are two times more likely to have a heart disease or stroke than people who do not [2]. It is therefore particularly interesting to METABOLIC AND HEMOSTATIC PARAMETERS IN PRE-DIABETES AND NEWLY DIAGNOSED TYPE 2 DIABETESPetrik G. G. Metabolic changes in diabetes mellitus are associated with hemostatic disorders. However, the sequence of hemostatic events in the early stages of disease remains unclear. Aim. to assess metabolic and hemostatic parameters and their interaction in pre-diabetes and newly diagnosed type 2 diabetes mellitus (Nd t2dM). Material and methods. the study enrolled volunteers of 40 to 65 years who considered themselves healthy and did not get any medication therapy. Of 170 examined individuals, 46 had impaired carbohydrate exchange (ICE) -13 with impaired fasting glucose, 17 -impaired glucose tolerance and 16 with Nd t2dM. the control group comprised healthy volunteers with normal body mass index and without signs of metabolic abnormalities. the metabolic (carbohydrate, lipid, protein exchange, hepatic transaminase), platelet and plasma hemostatic parameters (mean platelet volume, AdP-&collagen-induced platelet aggregation, coagulation profile, fibrinogen, plasminogen) were investigated. We identified the peculiarities initiating impact of changed parameters on different hemostatic components in patients with pre-diabetes and Nd t2dM. Results. Concentration of insulin, C-peptide, Homa-IR, total cholesterol demonstrated increase in groups with ICE. AdP-induced platelet aggregation, fibrinogen increased in ICE, however these changes were not statistically significant. Mean platelet volume and plasminogen had the tendency to be elevated in pre-diabetes and demonstrated significant increase in Nd t2dM. Conclusion. Metabolic disorders in prediabetic stage initiate changes in platelet hemostasis and fibrinolysis. the increase of MPV and higher concentrations of plasminogen are considered to be significant in Nd t2dM. Метаболические изменения при сахарном диабете (СД) сопряжены с наруше-ниями гемостаза, последовательность вовлечения компонентов которого на ранних стадиях заболевания не определена. Цель. Изучение параметров метаболизма, гемостаза и характера их взаимо-отношений при предиабете и впервые выявленном СД 2 типа (ВВ СД2). Материал и методы. Объектом исследования явились добровольцы в возра-сте 40-65 лет считающие себя здоровыми и не получающие никакой медика-ментозной терапии. У 46 из 170 обследованных выявлены нарушения углевод-ного обмена (НУО): 13 -нарушение гликемии натощак,17 нарушение толе-рантности к глюкозе и у 16 ВВ СД2. Контрольную группу составили 13 здоровых добровольцев с нормальной массой тела без признаков метаболически ано-мального фенотипа. Во всех континге...

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“…Cardiovascular diseases (CVD), a group of disorders that affect the heart and vasculature, are the most predominant form of NCDs, and the greatest cause of death globally (World Health Organisation, 2009;Yusuf et al, 2015). These include conditions such as coronary heart disease, cerebrovascular disease, stroke, and ischaemic heart disease.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…Therefore regular blood pressure measurement is vital for timely diagnosis before life-threatening complications develop. Improved control of hypertension on a global scale may significantly reduce the economic and public health burden of cardiovascular disease (Chow et al, 2013;Yusuf et al, 2015).…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Gestational hypoxia and programming of disease

Walton¹

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Fetal hypoxia remains the most common complication throughout pregnancy and has a wide aetiology including, but not limited to, placental insufficiency, high altitude living and maternal factors such as smoking and pulmonary disease. Intrauterine growth restriction and subsequent low birth weight are common features of pregnancies complicated by reduced oxygenation. Suboptimal organ development may arise, thereby substantially increasing vulnerability to cardiovascular and renal diseases in adulthood. Recently it has been established that prenatally programmed vulnerability to disease may be exacerbated by a postnatal 'second-hit', such as a high salt diet or ageing. The primary aim of this thesis was to investigate the effects of maternal hypoxia on the programming of cardiovascular and renal disease in mice, and secondly whether excess dietary salt intake throughout life may exacerbate disease outcomes.Pregnant CD1 mice were housed in a hypoxia chamber set to 12% oxygen throughout the last five days of pregnancy, from embryonic day (E) 14.5 until birth (P0). Control animals remained in normoxic room conditions (21% oxygen) throughout pregnancy. Upon littering, animals were removed from the hypoxia chamber and raised in normoxic room conditions. A subset of mice was fed a high salt diet from 10 weeks of age until post-mortem. Mice were housed in metabolic cages for 24 hours to assess renal function under basal conditions, and in response to a 24 hour water deprivation challenge, at 4 and 12 months of age. Blood pressure and microvascular function and structure were assessed in offspring at 12 months of age.Kidneys, hearts and aortas were collected for stereological and histological analyses.Prenatal hypoxia reduced nephron number in the kidneys of male offspring, leading to glomerular hypertrophy, renal fibrosis and mild albuminuria by 12 months of age. However, female offspring exposed to the same hypoxic insult in utero presented with normal number of glomeruli and renal pathology equivalent to control animals by 12 months of age. Both male and female hypoxia-exposed offspring had elevated mean arterial pressure at 12 months of age. A high salt diet throughout adult life increased cardiac tissue fibrosis, particularly in male hypoxia-exposed offspring, and exacerbated renal pathology in male hypoxia-exposed offspring only. Pressurized myography was performed at the time of post-mortem to assess functional, structural and mechanical properties of mesenteric resistance arteries at 12 months of age. Both male and female offspring exposed to maternal hypoxia had significantly 3 impaired endothelial function, which was not exacerbated by the high salt diet. The combination of prenatal hypoxia and a postnatal high salt diet caused marked stiffening of the microvasculature as well as loss of elastin integrity and increased collagen content in the aorta, consistent with vascular stiffness. This suggests that kidneys from female offspring are somehow protected from the in utero insult; however, this protection...

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The World Heart Federation's vision for worldwide cardiovascular disease prevention

Cited by 136 publications

References 22 publications

Integrating cardiovascular diseases, hypertension, and diabetes with HIV services: a systematic review

Integrating cardiovascular diseases, hypertension, and diabetes with HIV services: a systematic review

Metabolic and Hemostatic Parameters in Pre-Diabetes and Newly Diagnosed Type 2 Diabetes

Gestational hypoxia and programming of disease

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