The world first two cases of severe fever with thrombocytopenia syndrome: An epidemiological study in Nagasaki, Japan

Kurihara, Shintaro; Satoh, Akira; Yu, Fangfang; Hayasaka, Daisuke; Shimojima, Masayuki; Tashiro, Masato; Saijo, Tomomi; Takazono, Takahiro; Imamura, Yoshifumi; Miyazaki, Taiga; Tsukamoto, Misuzu; Yanagihara, Katsunori; Mukae, Hiroshi; Saijo, Masayuki; Morita, Kouichi; Kohno, Shigeru; Izumikawa, Koichi

doi:10.1016/j.jiac.2016.04.001

Cited by 26 publications

(15 citation statements)

References 12 publications

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“…Sever fever with thrombocytopenia syndrome (SFTS) is a recent confirmed tick-borne disease caused by the severe fever with thrombocytopenia syndrome virus (SFTSV), the virus which is classified in the family Phenuiviridae , genus Phlebovirus ( Yu et al, 2011 ). In 2009, the SFTSV was first identified in the rural area in central China, and after then although SFTS cases had been reported in other East Asia, including Japan ( Kurihara et al, 2016 ) and Korean ( Park et al, 2016 ), the most SFTS cases were reported in China. From 2011 to 2016, the annual case numbers increased year by year in China ( Sun et al, 2017 ), SFTS has already posed as a severe threat to public health.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Wei

et al. 2018

Front. Microbiol.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus, and the number of SFTS cases increased year by year in China. Previous studies had indicated that gut microbiome closely associated with human health and diseases, including infection diseases, liver diseases, gastrointestinal diseases and metabolic diseases. The aim of this study is to investigate the alterations and involvements of gut microbial in SFTS patients. We compared the gut microbiome of 26 SFTS patients between 20 health controls using the Illumina MiSeq sequencing platform. Reduced gut microbiota diversity and dramatic shifts of fecal microbial composition in SFTS patients were observed compared with health controls. In the intestinal microbial of SFTS patients, the Lachnospiraceae and Ruminococcaceae which could produce short-chain fatty acids were clearly dropped compared with health people, meanwhile, Sutterella which have anti-inflammation properties were reduced too. On the contrary, some common opportunistic pathogens like Enterococcus and Streptococcus and endotoxin-producing bacteria Escherichia which could rise the risk of infections were increased in SFTS patients than healthy people, in addition lactate-producing bacteria Lactobacillaceae also significantly increased in SFTS patients. In addition, research findings on the correlation between gut microbiota and biochemical data found that the changes of gut microbiota of SFTS patients were closely associated with clinical symptoms, key serum enzymes, infection and mortality. These alterations of gut microbiome in SFTS patients suggest the potential contributions of gut microbial to the pathogenesis of SFTS.

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Section: Introductionmentioning

confidence: 99%

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Wei

et al. 2018

Front. Microbiol.

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“…The other highlight was that the cluster comprising eleven SFTS patients occurred in Yixing County, China, in 1996, which preceded the cases in Japan in 2005 reported by Kurihara et al . that might be mistaken as the earliest SFTS cases worldwide[ 17 ]. Our result suggests that SFTS have existed for a long time without being recognized.…”

Section: Discussionmentioning

confidence: 99%

“…From the published documents, two SFTS cases in Japan in 2005 reported by Kurihara et al . have been regarded as the earliest cases in the world [ 17 ]. A recent phylogenetic study on SFTSV in China, South Korea, and Japan demonstrated that SFTSV could be divided into the Chinese clade and the Japanese clade, which may have evolved separately over time, except for the rare occasion of overseas transmission[ 18 ].These results suggest that SFTS may have existed without being identified for some time.…”

Section: Introductionmentioning

confidence: 99%

A cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus infection in China, 1996: A retrospective serological study

Shi²,

et al. 2018

PLoS Negl Trop Dis

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BackgroundA cluster of eleven patients, including eight family members and three healthcare workers with fever and thrombocytopenia occurred in Yixing County, Jiangsu Province, China, from October to November 1996. However, the initial investigation failed to identify its etiology. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS bunyavirus (SFTSV), which was first discovered in 2009. The discovery of novel SFTSV resulted in our consideration to test SFTSV on the remaining samples of this cluster in September 2010.Methodology/Principal findingsWe retrospectively analyzed the epidemiological and clinical data of this cluster. The first case, one 55-year-old man with fulminant hemorrhagic diseases, died on October 14, 1996. His younger brother (the second case) developed similar hemorrhagic diseases after nursing him and then died on November 3. From November 4 to November 15, nine other patients, including six family members and three medical staffs, developed fever and thrombocytopenia after exposure to the second case. The sera of six patients were collected on November 24, 1996. IgM antibodies against SFTSV were detected in all of the six patients’ sera using enzyme-linked immunosorbent assay (ELISA), while IgG antibodies were detected in one patient’s serum using an indirect immunofluorescence assay (IFA). We also found that IgG antibodies against SFTSV were still detected in four surviving patients’ sera 14 years after illness onset.Conclusions and significanceThe mysterious pathogen of the cluster in 1996 was proved to be SFTSV on the basis of its epidemiological data, clinical data and serological results. It suggests that SFTSV has been circulating in China for more than 10 years before being identified in 2009, and SFTSV IgG antibodies can persist for up to 14 years.

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“…From 2010 to 2016, over 10,000 SFTS cases, with an average mortality rate of 5.3%, were reported in 23 provinces in China according to the Chinese Disease Prevention and Control Information System 8 . The virus was then identified in Japan and South Korea 1 , 2 , 9 , 10 . SFTSV infections resulted in 46 reported deaths out of 170 confirmed SFTS cases in Japan (a mortality rate of 27.1%) until 2016 2 and 54 deaths out of 172 SFTS cases in South Korea (a mortality rate of 31.4%) until 2015 11 .…”

Section: Introductionmentioning

confidence: 99%

“…The virus was then identified in Japan and South Korea 1 , 2 , 9 , 10 . SFTSV infections resulted in 46 reported deaths out of 170 confirmed SFTS cases in Japan (a mortality rate of 27.1%) until 2016 2 and 54 deaths out of 172 SFTS cases in South Korea (a mortality rate of 31.4%) until 2015 11 . HRTV was identified from patients with clinical symptoms similar to those observed for SFTS in the United States in 2009, which has a close genetic relationship to SFTSV 5 .…”

Section: Introductionmentioning

confidence: 99%

A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen

Shěn

Xiao-mei

Wáng

et al. 2018

Emerging Microbes & Infections

117

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Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) and Heartland virus (HRTV) were recently identified as tick-borne phleboviruses (TBPVs) in Asia and the United States, respectively, and are associated with severe human diseases with similar clinical manifestations. In this study, we report the first identification and isolation of a novel TBPV named Guertu virus (GTV) from Dermacentor nuttalli ticks in Xinjiang Province, China, where TBPVs had not been previously discovered. Genome sequence and phylogenetic analyses showed that GTV is closely related to SFTSV and HRTV and was classified as a member of the genus Phlebovirus, family Phenuiviridae, order Bunyavirales. In vitro and in vivo investigations of the properties of GTV demonstrated that it was able to infect animal and human cell lines and can suppress type I interferon signaling, similar to SFTSV, that GTV nucleoprotein (NP) can rescue SFTSV replication by replacing SFTSV NP, and that GTV infection can cause pathological lesions in mice. Moreover, a serological survey identified antibodies against GTV from serum samples of individuals living in Guertu County, three of which contained neutralizing antibodies, suggesting that GTV can infect humans. Our findings suggested that this virus is a potential pathogen that poses a threat to animals and humans. Further studies and surveillance of GTV are recommended to be carried out in Xinjiang Province as well as in other locations.

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The world first two cases of severe fever with thrombocytopenia syndrome: An epidemiological study in Nagasaki, Japan

Cited by 26 publications

References 12 publications

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

A cluster of cases of severe fever with thrombocytopenia syndrome bunyavirus infection in China, 1996: A retrospective serological study

A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen

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