The working memory capabilities of the spontaneously hypertensive rat

Robertson, Barbara-Anne; Clements, K.M.; Wainwright, P.E.

doi:10.1016/j.physbeh.2008.02.016

Cited by 23 publications

(15 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The BN, Lewis, and WKY rats performed the short-term memory task well, corroborating findings for WKY rats [101] although Clement and colleagues [100] found no improvement across trials in a similar task using WKY rats. The performance of F344 rats was unstable across sessions, and they did not show improvement from odd to even trials in the second, third, and fourth sessions.…”

Section: Discussionsupporting

confidence: 70%

Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains

et al. 2009

View full text Add to dashboard Cite

BackgroundCognitive function might be affected by the subjects' emotional reactivity. We assessed whether behavior in different tests of emotional reactivity is correlated with performance in aversively motivated learning tasks, using four strains of rats generally considered to have a different emotional reactivity.MethodsThe performance of male Brown Norway, Lewis, Fischer 344, and Wistar Kyoto rats in open field (OF), elevated plus-maze (EPM), and circular light-dark preference box (cLDB) tasks, which are believed to provide measures of emotional reactivity, was evaluated. Spatial working and reference memory were assessed in two aversively motivated learning and memory tasks: the standard and the "repeated acquisition" versions of the Morris water maze escape task, respectively. All rats were also tested in a passive avoidance task. At the end of the study, levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid, and 5-HT turnover in the hippocampus and frontal cortex were determined.ResultsStrain differences showed a complex pattern across behavioral tests and serotonergic measures. Fischer 344 rats had the poorest performance in both versions of the Morris water escape task, whereas Brown Norway rats performed these tasks very well but the passive avoidance task poorly. Neither correlation analysis nor principal component analysis provided convincing support for the notion that OF, EPM, and cLDB tasks measure the same underlying trait.ConclusionsOur findings do not support the hypothesis that the level of emotional reactivity modulates cognitive performance in aversively motivated tasks. Concepts such as "emotional reactivity" and "learning and memory" cannot adequately be tapped with only one behavioral test. Our results emphasize the need for multiple testing.

show abstract

Section: Discussionsupporting

confidence: 70%

Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains

et al. 2009

View full text Add to dashboard Cite

show abstract

“…No choice has to be made by the rats, and no long training phases are necessary. Thus, the model could be interesting for a further characterisation of SHR and WKY rats since the group of Clements and Wainwright (Robertson et al 2008;Clements and Wainwright 2006) who thoroughly characterised the strains in different animal models of working memory concluded that an impaired performance of SHR in these models could be more due to impulsivity than deficient memory.…”

Section: Discussionmentioning

confidence: 99%

Comparison of SHR, WKY and Wistar rats in different behavioural animal models: effect of dopamine D1 and alpha2 agonists

Langen

Dost

2010

ADHD Atten Def Hyp Disord

View full text Add to dashboard Cite

Spontaneously hypertensive rats (SHR) and its counterpart, the Wistar-Kyoto rats (WKY), are probably the most often used animal model of ADHD. However, SHR as model of ADHD have also been criticised partly because of not differing to outbred rat strains. In the present study, adolescent SHR, WKY and Wistar rats from Charles River were tested in open-field, elevated plus maze and novel object recognition and on gastrointestinal transport to more intensively evaluate the strain characteristics. Non-habituated SHR and Wistar rats were more active than WKY rats but contrary to Wistar rats SHR stay hyperactive in a familiar environment. SHR were more sensitive to the alpha2-adrenoceptor agonist guanfacine and the dopamine D1 agonist A-68930 than WKY and Wistar rats, whereas amphetamine, the D1/D5 agonist ABT431 and the D2 agonist quinpirole, similarly affected open-field activity in all strains. In the elevated plus maze, SHR and Wistar rats showed less anxiety-related behaviour than WKY rats. Guanfacine and amphetamine induced an anxiolytic-like activity in SHR but not in WKY and Wistar rats. SHR showed the highest long-term memory in the novel object recognition. Gastrointestinal transport was similar and comparably affected by guanfacine in all rat strains. The present study shows clear differences in the behaviour of SHR and Wistar rats but also of WKY and Wistar rats. The use of SHR as animal model of ADHD is supported.

show abstract

“…Results with WKY rats are somewhat controversial, as some studies have suggested relative poor spatial learning/memory ability in the MWM (e.g. [59,60]), while others have found quite good efficiency in some MWM tasks, even compared with BN and F344 strains [30,61]. There is, however, no comprehensive study simultaneously comparing the eight progenitor strains of the NIH-HS stock in spatial learning/memory, which makes it extremely difficult to ascertain, or even to hypothesize any relationship between the observed relatively good spatial learning/memory efficiency of NIH-HS rats and their genetic background.…”

Section: Figmentioning

confidence: 99%

Spatial learning in the genetically heterogeneous NIH-HS rat stock and RLA-I/RHA-I rats: Revisiting the relationship with unconditioned and conditioned anxiety

Martínez-Membrives

López-Aumatell

Blázquez

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

The working memory capabilities of the spontaneously hypertensive rat

Cited by 23 publications

References 41 publications

Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains

Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains

Comparison of SHR, WKY and Wistar rats in different behavioural animal models: effect of dopamine D1 and alpha2 agonists

Spatial learning in the genetically heterogeneous NIH-HS rat stock and RLA-I/RHA-I rats: Revisiting the relationship with unconditioned and conditioned anxiety

Contact Info

Product

Resources

About