Cognitive task analysis (CTA) methods are most widely known for their contributions to military, nuclear power plant, and aviation research. In recent years, however, these methods have been adapted and applied with increasing frequency to address issues in healthcare. CTA methods have been used in the context of designing and integrating health information technology, in pursuit of improved patient safety, and as a means to improve education and training. This panel will 1) reflect on strategies for tailoring CTA methods for use in a range of healthcare settings, 2) highlight challenges to conducting CTA in healthcare settings, and 3) highlight important contributions of CTA in addressing challenging issues in healthcare today.Summary: A relatively recent confluence of events has led to an increased demand for understanding cognitive complexity in healthcare. Calls to increase safety in healthcare settings have led to efforts to better understand the challenges that healthcare professionals, as well as patients and caregivers, face in planning, tracking, and managing care. Medical device manufacturers have been encouraged to place a greater emphasis on understanding where end users are likely to get confused, and to build designs that increase the likelihood of error detection, and reduce errors where possible. The relatively rapid transition from paper to electronic health records has driven increased interest in understanding the impact of health information technology on assessment, decision making, sensemaking, and other critical cognitive skills. This panel will explore how cognitive task analysis methods (CTA) have been used to better understand cognitive complexity in healthcare. Panelists have diverse experiences and backgrounds. Each will share his or her own experiences tailoring CTA methods for use in healthcare. Panel presentations will address a range of important healthcare problems including strategies for learning from adverse events, invisible aspects of RN work, decision making strategies pharmacists and physicians use to avoid drug-drug interactions and manage medication alerts. In addition, panelists will discuss CTA methodological challenges such as investigating cognition at a team or system level, eliciting difficult to articulate knowledge such as mental models and knowledge representations, and analyzing qualitative data.