The wing and the eye: a parsimonious theory for scaling and growth control?

Romanova‐Michaelides, Maria; Aguilar-Hidalgo, Daniel; Jülicher, Frank; González‐Gaitán, Marcos

doi:10.1002/wdev.195

Cited by 23 publications

(28 citation statements)

References 87 publications

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“…Then as the discs approach their final sizes, the levels of Dpp will begin to fall thereby slowing the rate of growth. Ultimately Dpp levels drop below a certain "proliferation inducing" threshold and the disc ceases to grow any further (Romanova-Michaelides et al, 2015).…”

Section: Cell Proliferation: Knowing When To Stop Growingmentioning

confidence: 99%

The fly eye: Through the looking glass

Kumar

2017

Developmental Dynamics

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The developing eye-antennal disc of Drosophila melanogaster has been studied for more than a century, and it has been used as a model system to study diverse processes, such as tissue specification, organ growth, programmed cell death, compartment boundaries, pattern formation, cell fate specification, and planar cell polarity. The findings that have come out of these studies have informed our understanding of basic developmental processes as well as human disease. For example, the isolation of a white-eyed fly ultimately led to a greater appreciation of the role that sex chromosomes play in development, sex determination, and sex linked genetic disorders. Similarly, the discovery of the Sevenless receptor tyrosine kinase pathway not only revealed how the fate of the R7 photoreceptor is selected but it also helped our understanding of how disruptions in similar biochemical pathways result in tumorigenesis and cancer onset. In this article, I will discuss some underappreciated areas of fly eye development that are fertile for investigation and are ripe for producing exciting new breakthroughs. The topics covered here include organ shape, growth control, inductive signaling, and right-left symmetry. Developmental Dynamics 247:111-123, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Cell Proliferation: Knowing When To Stop Growingmentioning

confidence: 99%

The fly eye: Through the looking glass

Kumar

2017

Developmental Dynamics

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“…The second term describes the change in auxin concentration as result of dilution of auxin due to an increase in cell area due to cell area growth. Similar situation of an area growth induced dilution of a chemical specie, growth hormone, morphogens, etc., is encountered in other biological systems (Romanova-Michaelides et al, 2015; Wartlick et al, 2011).…”

Section: Methodsmentioning

confidence: 98%

Tissue specific auxin biosynthesis regulates leaf vein patterning

Kneuper

Teale

Dawson

et al. 2017

Preprint

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23peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/184275 doi: bioRxiv preprint first posted online Sep. 4, 2017; 2 Highlights 24• Built spatially and temporally resolved auxin biosynthesis map in growing leaf primordium of 25Arabidopsis. 26• Expression domains of auxin biosynthetic enzymes within primordia strongly correlated with leaf 27 vein initiation. 28• Results show that domains of auxin biosynthesis within primordia drive leaf vein initiation and 29 patterning. 31 Summary 32The plant hormone auxin (indole-3-acetic acid, IAA) has a profound influence over plant cell growth 33 and differentiation. Current understanding of vein development in leaves is based on the canalization 34 of auxin into self-reinforcing streams which determine the sites of vascular cell differentiation. 35However, the role of auxin biosynthesis during leaf development in the context of leaf vein patterning 36 has not been much studied so far. Here we characterize the context specific importance of auxin 37 biosynthesis, auxin transport and mechanical regulations in a growing leaf. We show that domains of

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“…These patterns have been related to the statistics of epithelial tissues, regarding a multiscale proof of spatial particularities of biological organization. 9,10,15,16 The spatial regions are limited by circles around “fairy circles,” where the center is the centroid of Voronoi polygons, as shown in section “Spatial regions and random points, as basic tools for developing Voronoi tessellation treatment.” The number of regions is not fixed because there are 5 different images (Figure 7). …”

Section: Methodsmentioning

confidence: 99%

A Method to Categorize 2-Dimensional Patterns Using Statistics of Spatial Organization

López-Sauceda

Rueda-Contreras

2017

Evol Bioinform Online

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We developed a measurement framework of spatial organization to categorize 2-dimensional patterns from 2 multiscalar biological architectures. We propose that underlying shapes of biological entities can be approached using the statistical concept of degrees of freedom, defining it through expansion of area variability in a pattern. To help scope this suggestion, we developed a mathematical argument recognizing the deep foundations of area variability in a polygonal pattern (spatial heterogeneity). This measure uses a parameter called eutacticity. Our measuring platform of spatial heterogeneity can assign particular ranges of distribution of spatial areas for 2 biological architectures: ecological patterns of Namibia fairy circles and epithelial sheets. The spatial organizations of our 2 analyzed biological architectures are demarcated by being in a particular position among spatial order and disorder. We suggest that this theoretical platform can give us some insights about the nature of shapes in biological systems to understand organizational constraints.

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The wing and the eye: a parsimonious theory for scaling and growth control?

Cited by 23 publications

References 87 publications

The fly eye: Through the looking glass

The fly eye: Through the looking glass

Tissue specific auxin biosynthesis regulates leaf vein patterning

A Method to Categorize 2-Dimensional Patterns Using Statistics of Spatial Organization

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