The Willingness to Change Risky Health Behaviors among Chinese Rural Residents: What We Learned from a Population-Based Esophageal Cancer Cohort Study

Liu, Mengfei; Zhang, Chanyuan; Cai, Hong; Liu, Fangfang; Ying, Liu; Li, Jingjing; Pan, Yaqi; Guo, Chuanhai; He, Zhonghu; Ke, Yang

doi:10.1371/journal.pone.0161999

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…The major histologic type of EC in China is ESCC, which accounts for 90% of new cases, while adenocarcinoma is more common in Western countries (18–20). The pooled results (Table 3) show that the 5-years survival rate of SCC (15.5%, 95% CI: 12.4–18.6%) was significantly lower than that of ESCC (41.7%, 95% CI: 32.4–51.0%).…”

Section: Resultsmentioning

confidence: 99%

Survival of Esophageal Cancer in China: A Pooled Analysis on Hospital-Based Studies From 2000 to 2018

et al. 2019

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Background: Esophageal cancer (EC) causes more than 400 thousand deaths per year, and half of them occur in China. There are discrepancies regarding the survival of EC patients between population-based surveillance studies and hospital-based studies. Objectives: We aimed to synthesize the survival data from hospital-based EC studies in the Chinese population from 2000 to 2018 and to compare the survival rates between EC patients with different clinical classifications. Methods: The protocol of this systematic review was registered in PROSPERO (CRD-42019121559). We searched Embase, PubMed, CNKI, and Wanfang databases for studies published between January 1, 2000 and December 31, 2018. We calculated the pooled survival rates and 95% confidence intervals (CIs) by Stata software (V14.0). Results: Our literature search identified 933 studies, of which 331 studies with 79,777 EC patients met the inclusion criteria and were included in meta-analyses. The pooled survival rates were 74.1% (95% CI: 72.6–75.7%) for 1-year survival, 49.0% (95% CI: 44.2–53.8%) for 2-years survival, 46.0% (95% CI: 42.6–49.5%) for 3-years survival, and 40.1% (95% CI: 33.7–46.4%) for 5-years survival. An increased tendency toward EC survival was verified from 2000 to 2018. In addition, discrepancies were observed between EC patients with different clinical classifications (e.g., stages, histologic types, and cancer sites). Conclusions: Our findings showed a higher survival rate in hospital-based studies than population-based surveillance studies. Although this hospital-based study is subject to potential representability and publication bias, it offers insight into the prognosis of patients with EC in China.

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Section: Resultsmentioning

confidence: 99%

Survival of Esophageal Cancer in China: A Pooled Analysis on Hospital-Based Studies From 2000 to 2018

et al. 2019

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“…EAC is more prevalent in Western countries, whereas ESCC is more common in East Asian countries, such as China, Indian, and Iran [4] . In China, more than 90% of esophageal cancer cases were ESCC [ 5 , 6 ]. ESCC is a highly aggressive form of squamous cell carcinoma with a 5-year survival rate of less than 20% [1] .…”

Section: Introductionmentioning

confidence: 99%

Transcriptomics based multi-dimensional characterization and drug screen in esophageal squamous cell carcinoma

Chen

et al. 2021

EBioMedicine

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Background Esophageal squamous cell carcinoma (ESCC) remains one of the deadly cancer types. Comprehensively dissecting the molecular characterization and the heterogeneity of ESCC paves the way for developing more promising therapeutics. Methods Expression profiles of multiple ESCC datasets were integrated. ATAC-seq and RNA-seq were combined to reveal the chromatin accessibility features. A prognosis-related subtype classifier (PrSC) was constructed, and its association with the tumor microenvironment (TME) and immunotherapy was assessed. The key gene signature was validated in clinical samples. Based on the TME heterogeneity of ESCC patients, potential subtype-specific therapeutic agents were screened. Findings The common differentially expressed genes (cDEGs) in ESCC were identified. Up-regulated genes (HEATR1, TIMELESS, DTL, GINS1, RUVBL1, and ECT2) were found highly important in ESCC cell survival. The expression alterations of PRIM2, HPGD, NELL2, and TFAP2B were associated with chromatin accessibility changes. PrSC was a robust scoring tool that was not only associated with the prognosis of ESCC patients, but also could reflect the TME heterogeneity. TNS1 high fibroblasts were associated with immune exclusion. TG-101348 and Vinorelbine were identified as potential subtype-specific therapeutic agents. Besides, the application of PrSC into two immunotherapy cohorts indicated its potential value in assessing treatment response to immunotherapy. Interpretation Our study depicted the multi-dimensional characterization of ESCC, established a robust scoring tool for the prognosis assessment, highlighted the role of TNS1 high fibroblasts in TME, and identified potential drugs for clinical use. Funding A full list of funding bodies that contributed to this study can be found in the Acknowledgements section.

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“…Some studies have found that measures of alcohol intake differ with age, race/ethnicity, socioeconomic factors, and family history of cancer. [16][17][18][19] However, other studies have found that there is no association between alcohol intake and family history of breast cancer specifically. [20][21][22] In terms of willingness to decrease alcohol intake for health reasons, a recent study found that intent to decrease alcohol intake was negatively associated with age; 23 however, this study only included women at elevated risk for breast cancer, and these findings may not be applicable to women in the broader patient community, which include women with different levels of risk.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Women’s Unwillingness to Decrease Alcohol Intake to Decrease Breast Cancer Risk

Matin

Lucia

Lal

et al. 2021

J Prim Care Community Health

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Objective: Alcohol intake is a known risk factor for breast cancer. National organizations recommend that women consume no more than one serving of alcohol per day, if at all; however, many women exceed this recommendation, and some are unwilling to decrease consumption. Our study sought to identify factors associated with women’s unwillingness to decrease their alcohol intake to decrease their breast cancer risk. Methods: 942 women in a screening mammography cohort were asked questions about their demographics, personal and family health history, lifestyle factors, and willingness/unwillingness to decrease alcohol intake to decrease their breast cancer risk. Univariate and multivariate analyzes of their responses were performed. Results: 13.2% of women in our cohort indicated they were unwilling to decrease their alcohol intake to reduce their breast cancer risk. After adjusting for potential confounders, women who were 60 years and older were more than twice as unwilling to decrease their alcohol intake compared to their younger counterparts ( P = .0002). Women who had an annual household income of more than $200,000 were 1.75 times more unwilling to decrease their alcohol intake compared to their less affluent counterparts ( P = .033). Unwillingness was not significantly associated with race/ethnicity, education, having a first-degree family member with cancer, health perception, breast cancer risk perception, or BMI. Conclusions: Levels of unwillingness to decrease alcohol intake differed by age and household income. An opportunity is present to potentially decrease breast cancer risk in the community by educating women, especially older and more affluent women, about alcohol as a risk factor for breast cancer and the importance of limiting one’s alcohol intake.

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The Willingness to Change Risky Health Behaviors among Chinese Rural Residents: What We Learned from a Population-Based Esophageal Cancer Cohort Study

Cited by 5 publications

References 26 publications

Survival of Esophageal Cancer in China: A Pooled Analysis on Hospital-Based Studies From 2000 to 2018

Survival of Esophageal Cancer in China: A Pooled Analysis on Hospital-Based Studies From 2000 to 2018

Transcriptomics based multi-dimensional characterization and drug screen in esophageal squamous cell carcinoma

Factors Associated with Women’s Unwillingness to Decrease Alcohol Intake to Decrease Breast Cancer Risk

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