The wide presence of fluorinated compounds in common chemical products and the environment: a review

Zhang, Weilan; Liang, Yanna

doi:10.1007/s11356-023-30033-6

Environ Sci Pollut Res

2023

DOI: 10.1007/s11356-023-30033-6

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The wide presence of fluorinated compounds in common chemical products and the environment: a review

Weilan Zhang,

Yanna Liang

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2024

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Cited by 3 publications

References 118 publications

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Fluorinated Organic Polymers for Cancer Drug Delivery

Xin,

Lu,

Cao

et al. 2024

Advanced Materials

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In the realm of cancer therapy, the spotlight is on nanoscale pharmaceutical delivery systems, especially polymer‐based nanoparticles, for their enhanced drug dissolution, extended presence in the bloodstream, and precision targeting achieved via surface engineering. Leveraging the amplified permeation and retention phenomenon, these systems concentrate therapeutic agents within tumor tissues. Nonetheless, the hurdles of systemic toxicity, biological barriers, and compatibility with living systems persist. Fluorinated polymers, distinguished by their chemical idiosyncrasies, are poised for extensive biomedical applications, notably in stabilizing drug metabolism, augmenting lipophilicity, and optimizing bioavailability. Material science heralds the advent of fluorinated polymers that, by integrating fluorine atoms, unveil a suite of drug delivery merits: the hydrophobic traits of fluorinated alkyl chains ward off lipid or protein disruption, the carbon‐fluorine bond's stability extends the drug's lifecycle in the system, and a lower alkalinity coupled with a diminished ionic charge bolsters the drug's ability to traverse cellular membranes. This comprehensive review delves into the utilization of fluorinated polymers for oncological pharmacotherapy, elucidating their molecular architecture, synthetic pathways, and functional attributes, alongside an exploration of their empirical strengths and the quandaries they encounter in both experimental and clinical settings.This article is protected by copyright. All rights reserved

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Fluorinated Organic Polymers for Cancer Drug Delivery

Xin,

Lu,

Cao

et al. 2024

Advanced Materials

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Continuing benefits of the Montreal Protocol and protection of the stratospheric ozone layer for human health and the environment

Madronich,

Bernhard,

Neale

et al. 2024

Photochem Photobiol Sci

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The protection of Earth’s stratospheric ozone (O3) is an ongoing process under the auspices of the universally ratified Montreal Protocol and its Amendments and adjustments. A critical part of this process is the assessment of the environmental issues related to changes in O3. The United Nations Environment Programme’s Environmental Effects Assessment Panel provides annual scientific evaluations of some of the key issues arising in the recent collective knowledge base. This current update includes a comprehensive assessment of the incidence rates of skin cancer, cataract and other skin and eye diseases observed worldwide; the effects of UV radiation on tropospheric oxidants, and air and water quality; trends in breakdown products of fluorinated chemicals and recent information of their toxicity; and recent technological innovations of building materials for greater resistance to UV radiation. These issues span a wide range of topics, including both harmful and beneficial effects of exposure to UV radiation, and complex interactions with climate change. While the Montreal Protocol has succeeded in preventing large reductions in stratospheric O3, future changes may occur due to a number of natural and anthropogenic factors. Thus, frequent assessments of potential environmental impacts are essential to ensure that policies remain based on the best available scientific knowledge. Graphical abstract

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HFIP-Promoted Divergent Cycloadditions of Difluoroenoxysilanes with 2-Indolylmethanols: Synthesis of Fluoro 2H-Pyrano[3,4-b]indoles and gem-Difluoro Cyclopenta[b]indoles

Li,

Zhang,

Sun

et al. 2024

Org. Lett.

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The wide presence of fluorinated compounds in common chemical products and the environment: a review

Cited by 3 publications

References 118 publications

Fluorinated Organic Polymers for Cancer Drug Delivery

Fluorinated Organic Polymers for Cancer Drug Delivery

Continuing benefits of the Montreal Protocol and protection of the stratospheric ozone layer for human health and the environment

HFIP-Promoted Divergent Cycloadditions of Difluoroenoxysilanes with 2-Indolylmethanols: Synthesis of Fluoro 2H-Pyrano[3,4-b]indoles and gem-Difluoro Cyclopenta[b]indoles

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