2022
DOI: 10.21203/rs.3.rs-1286002/v1
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The Whole-Transcriptome Landscape of Diabetes-Related Sarcopenia Reveals the Specific Function of Novel lncRNA Gm20743

Abstract: Background: While the exact mechanism remains unclear, type 2 diabetes mellitus (T2DM) has been shown to increase the risk of sarcopenia that is characterized by decreased muscle mass, strength, and function. This study aimed to identify the pathophysiological role of lncRNAs in diabetic sarcopenia. Methods: Whole-transcriptome RNA sequencing was performed on the gastrocnemius from the overt diabetes-induced sarcopenia model of db/db mice. Informatics and co-expression networks were performed to predict key ln… Show more

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“…MiR-126a-5p, as a novel member of the miRNA family, has been found to be involved in traumatic fractures of the brain, tumors, osteoarthritis, endothelial cell injury of coronary heart disease, myocardial cell brosis and other aspects (Yu et al, 2022). However, the role of miR-126a-5p in AIS and neuronal injury has not been reported.…”
Section: Discussionmentioning
confidence: 99%
“…MiR-126a-5p, as a novel member of the miRNA family, has been found to be involved in traumatic fractures of the brain, tumors, osteoarthritis, endothelial cell injury of coronary heart disease, myocardial cell brosis and other aspects (Yu et al, 2022). However, the role of miR-126a-5p in AIS and neuronal injury has not been reported.…”
Section: Discussionmentioning
confidence: 99%