The Whole Systems Medicine of Tomorrow: A Half-Century Perspective

Manahan, Bill

doi:10.1016/j.explore.2011.04.007

Cited by 6 publications

(3 citation statements)

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“…We have proved that treatments derived from clinical trials are deemed to be poor or inherently dangerous due to mismatched application [9]. Besides the mismatch of treatment, the poor performance of population-based treatments can be attributed to reductionist approach, which is found to be poor or unworkable in nutrition [114][115], lower back pain [116], neuroscience and brain research [117][118], diagnostics [119], exercise [120], patient care [121][122][123][124][125][126][127][128][129][130][131][132], public health programs [124], and holistic medicine [125][126][127]150]. The evidence, taken as whole, has firmly established that reductionist treatments are inferior.…”

Section: Failure Of Reductionist Treatment Modelmentioning

confidence: 99%

Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases Due to Flawed Presumptions

Wu¹,

Zha²

2020

Preprint

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Modern medicine adopted four presumptions when it evolved from ancient experienced-based mind-body medicine. To understand its failure in finding cures for chronic diseases, we examined four presumptions, and found that statistical population of health properties does not exist for most research purposes, mathematical models are misused to model intensive properties, synthetic drugs are inherently more dangerous than nature-made medicines under their respective application conditions, and reductionist treatments are inferior and inherently dangerous. We found that clinical trials are valid only for research where treatment effect is much stronger than the total effects of all interfering or co-causal factors or errors introduced by misused mathematical models can be tolerated. In all other situations, clinical trials introduce excessive errors and fail to detect treatment effects, or produce biased, incorrect or wrong results. We further found that chronic diseases are manifestation of small departures in multiple process attributes in distinctive personal biological pathways networks, that modern medicine lacks required accuracy for accurately characterizing chronic diseases, and that reductionist treatments are good at controlling symptoms and safe for short term uses. For all stated reasons, as long as modern medicine continues relying on the flawed presumptions, it can never find predictable cures for chronic diseases. By implication, predictable cures to chronic diseases are adjustments to lifestyle, dietary, emotional, and environmental factors to slowly correct departures in process attributes responsible for chronic diseases.

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Section: Failure Of Reductionist Treatment Modelmentioning

confidence: 99%

Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases Due to Flawed Presumptions

Wu¹,

Zha²

2020

Preprint

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“…Thus, a drug intervening one single target mechanism cannot be a cure for the disease. The reductionist approach focusing on one single or few steps are consistently found to be poor [330][331][332][333][334][335][336][337][338][339][340][341]. After many organ functions have been impaired with the driving force to continue inflicting more damages to tissue, a cure cannot be a synthetic drug for altering one step in the immune system or viral replication process.…”

Section: Benefits Of Antiviral Drugsmentioning

confidence: 99%

“…At the early time, it was not understood that vital organs have massive redundant functions and the existence of so many lifestyle factors. The flaw is also revealed in the reductionist treatment approach, which is found to be poor consistently [327][328][329][330][331][332][333][334][335][336][337][338][339][340][341]. Many of those problems have been found after 1980, medicine lacks any incentive and channel to correct them because interest holders promote medicalization.…”

Section: Overwhelming Evidence Refutes the Drug Tenetmentioning

confidence: 99%

Proactive Body Temperature Management Protocol and Lifestyle Interventions as Predictable Cures for COVID-19 Disease: Curative Protocols Discovered from a Century of Medical Discoveries

Wu¹,

Zha²

2020

Preprint

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Based on a century of medical discoveries, we propose a methodology of using lifestyle interventions and proactive body temperature management protocol as prevention and cure for COVID-19 disease. We produce robust evidence to show that lifestyle interventions have a 100% “expected response rate”, with a curative power being one to three orders of magnitude larger than that of a single lifestyle factor determined by clinical trials and can deliver immediate benefits to long-term curative benefits. On basis of a large number of studies, we propose that the local blood flow along the inner surface of the respiratory track works like an anti-viral shield, which is capable of robustly prevent and terminate viral and other infections. Breathing cold temperature from 26 °C to a frigid temperature can dramatically reduce local temperatures along the track and thus cripples the protective shield by reducing local blood flow to as little as 3-10%. A proactive body temperature management protocol (PBTM or PRTPM), which comprises pre-exposure, during-exposure, and post-exposure measures, are capable of boosting innate immune functions, anti-viral defenses, and vital organ functions. We estimate that pre-exposure and during-exposure measures can reduce temperature drops along the tract by 5°C to 20 °C, and that a series of post-exposure measures can increase local blood flow rates along the track by 2 to 20 times. The proposed measures can completely restore the anti-viral shield. All kinds epidemiological data support our estimated curative power that the protocol can prevent 90% to 97% infection incidences and deaths. We show that the protocol is even more powerful than vaccine, and maintaining a reasonable local temperature along the respiratory track is a required condition for delivering and boosting vaccine’s protection.Current medical researches have excluded temperature and air as treatments in all on-going clinical trials. This misplaced priority is an inevitable result of the financial arrangement of all parties in medicine. Such financial arrangement provides too much incentive for medicalization, the key elements of which include finding revenue-making treatments, producing good data for promoting the treatments, and finding more patients for using treatments. Since lifestyle interventions and proactive body temperature management protocol cannot be studied by flawed research model and cannot be patented for monopoly, no entity has incentives to explore their extraordinary benefits. We also found that the reason of failure to contain the COVID-19 pandemic is same as failure to find cures for cancer and AIDS. Several studies imply that best solutions for cancer, AIDS and all chronic diseases are not revenue-generating medical treatments, but things that cannot sold for revenues and things that are born and carried in human genome. Based on a century of medical discoveries in disease causes, we propose for the federal government that the most cost-effective measures are finding and eliminating a large number of disease causes hidden in food production lines, family kitchens, cooking culture, personal cooking habits, home appliances, etc. This is the only way to root out causes for more than 90% chronic diseases incidences.

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Patient and Family Engagement in the United States: A Social Movement from Patient to Advocate to Partner

Maurer

Dardess

Rouse

2019

Organizational Behaviour in Healthcare

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The Whole Systems Medicine of Tomorrow: A Half-Century Perspective

Cited by 6 publications

References 0 publications

<b>Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases </b><b>Due to Flawed </b><b>Presumptions</b>

<b>Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases </b><b>Due to Flawed </b><b>Presumptions</b>

Proactive Body Temperature Management Protocol and Lifestyle Interventions as Predictable Cures for COVID-19 Disease: Curative Protocols Discovered from a Century of Medical Discoveries

Patient and Family Engagement in the United States: A Social Movement from Patient to Advocate to Partner

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